Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta

Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta

Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...

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Bibliographic Details
Main Authors: Sarah Reagan-Steiner, Julu Bhatnagar, Roosecelis B. Martines, Nicholas S. Milligan, Carly Gisondo, Frank B. Williams, Elizabeth Lee, Lindsey Estetter, Hannah Bullock, Cynthia S. Goldsmith, Pamela Fair, Julie Hand, Gillian Richardson, Kate R. Woodworth, Titilope Oduyebo, Romeo R. Galang, Rebecca Phillips, Elizaveta Belyaeva, Xiao-Ming Yin, Dana Meaney-Delman, Timothy M. Uyeki, Drucilla J. Roberts, Sherif R. Zaki
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2022-03-01
Series:Emerging Infectious Diseases
Subjects:
COVID-19
2019 novel coronavirus disease
coronavirus disease
severe acute respiratory syndrome coronavirus 2
SARS-CoV-2
vertical transmission
Online Access:https://wwwnc.cdc.gov/eid/article/28/3/21-1735_article
Description
Summary:Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and preeclampsia. We observed severe diffuse alveolar damage and localized SARS-CoV-2 by immunohistochemistry, in situ hybridization, and electron microscopy of the lungs of the neonate. We localized SARS-CoV-2 RNA in neonatal heart and liver vascular endothelium by using in situ hybridization and detected SARS-CoV-2 RNA in neonatal and placental tissues by using reverse transcription PCR. Subgenomic reverse transcription PCR suggested viral replication in lung/airway, heart, and liver. These findings indicate that in utero SARS-CoV-2 transmission contributed to this neonatal death.
ISSN:1080-6040
1080-6059

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