Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs
ABSTRACT: This study compared cardiovascular and respiratory effects of dexmedetomidine and xylazine in total intravenous anesthesia with propofol, ketamine, and lidocaine. Twenty-one female dogs were submitted to ovariohysterectomy, premedicated with acepromazine and anesthetized with propofol at a...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Maria
2023-12-01
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| Series: | Ciência Rural |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782024000600601&lng=en&tlng=en |
| _version_ | 1797386403654402048 |
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| author | Gustavo Antônio Boff Camila Moura de Lima Luã Borges Iepsen Márcia de Oliveira Nobre Martielo Ivan Gehrcke |
| author_facet | Gustavo Antônio Boff Camila Moura de Lima Luã Borges Iepsen Márcia de Oliveira Nobre Martielo Ivan Gehrcke |
| author_sort | Gustavo Antônio Boff |
| collection | DOAJ |
| description | ABSTRACT: This study compared cardiovascular and respiratory effects of dexmedetomidine and xylazine in total intravenous anesthesia with propofol, ketamine, and lidocaine. Twenty-one female dogs were submitted to ovariohysterectomy, premedicated with acepromazine and anesthetized with propofol at a variable rate. The dogs were intubated and supplemented with 100% oxygen in a circuit without rebreathing gases in spontaneous ventilation. They were divided into three groups (n=21) after induction: control (CON) with ketamine (2 mg/kg + 0.6 mg/kg/h) and lidocaine (2 mg/kg + 3 mg/kg/h), DEX and XIL with the same drugs as CON, associated with dexmedetomidine (2 µg/kg + 1 µg/kg/h) or xylazine (0.2 mg/kg + 0.1 mg/kg/h). Propofol consumption, fentanyl analgesic rescue, and cardiorespiratory and blood gas parameters were evaluated during anesthesia. The DEX group had a lower consumption of propofol (0.16 ± 0.09 mg/kg/min) compared to CON (0.24 ± 0.09 mg/kg/min), both not differing from XIL (0.23 ± 0.09 mg/kg/min). The mean arterial pressure was higher after the initial bolus in DEX (107 ± 8 mmHg) and XIL (96 ± 11 mmHg) compared to the CON group (80 ± 10 mmHg). Higher accumulation of arterial carbon dioxide and a decrease in pH were observed in the CON group. The total number of fentanyl rescues did not differ between DEX (7) and XIL (6) and were lower than CON (16). Therefore, dexmedetomidine and xylazine reduced intraoperative fentanyl consumption compared to ketamine and lidocaine infusion alone. However, only dexmedetomidine promoted lower propofol consumption and higher blood pressure values. |
| first_indexed | 2024-03-08T22:08:54Z |
| format | Article |
| id | doaj.art-dbbab0fb69ac497eb845c3e1e073704e |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-03-08T22:08:54Z |
| publishDate | 2023-12-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-dbbab0fb69ac497eb845c3e1e073704e2023-12-19T07:48:56ZengUniversidade Federal de Santa MariaCiência Rural1678-45962023-12-0154610.1590/0103-8478cr20220323Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogsGustavo Antônio Boffhttps://orcid.org/0000-0002-5837-5302Camila Moura de Limahttps://orcid.org/0000-0001-9306-705XLuã Borges Iepsenhttps://orcid.org/0000-0003-2744-5600Márcia de Oliveira Nobrehttps://orcid.org/0000-0003-3284-9167Martielo Ivan Gehrckehttps://orcid.org/0000-0002-5395-8082ABSTRACT: This study compared cardiovascular and respiratory effects of dexmedetomidine and xylazine in total intravenous anesthesia with propofol, ketamine, and lidocaine. Twenty-one female dogs were submitted to ovariohysterectomy, premedicated with acepromazine and anesthetized with propofol at a variable rate. The dogs were intubated and supplemented with 100% oxygen in a circuit without rebreathing gases in spontaneous ventilation. They were divided into three groups (n=21) after induction: control (CON) with ketamine (2 mg/kg + 0.6 mg/kg/h) and lidocaine (2 mg/kg + 3 mg/kg/h), DEX and XIL with the same drugs as CON, associated with dexmedetomidine (2 µg/kg + 1 µg/kg/h) or xylazine (0.2 mg/kg + 0.1 mg/kg/h). Propofol consumption, fentanyl analgesic rescue, and cardiorespiratory and blood gas parameters were evaluated during anesthesia. The DEX group had a lower consumption of propofol (0.16 ± 0.09 mg/kg/min) compared to CON (0.24 ± 0.09 mg/kg/min), both not differing from XIL (0.23 ± 0.09 mg/kg/min). The mean arterial pressure was higher after the initial bolus in DEX (107 ± 8 mmHg) and XIL (96 ± 11 mmHg) compared to the CON group (80 ± 10 mmHg). Higher accumulation of arterial carbon dioxide and a decrease in pH were observed in the CON group. The total number of fentanyl rescues did not differ between DEX (7) and XIL (6) and were lower than CON (16). Therefore, dexmedetomidine and xylazine reduced intraoperative fentanyl consumption compared to ketamine and lidocaine infusion alone. However, only dexmedetomidine promoted lower propofol consumption and higher blood pressure values.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782024000600601&lng=en&tlng=eninfusion ratealpha-2 adrenergic agonistsanalgesiasparing effectneutering |
| spellingShingle | Gustavo Antônio Boff Camila Moura de Lima Luã Borges Iepsen Márcia de Oliveira Nobre Martielo Ivan Gehrcke Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs Ciência Rural infusion rate alpha-2 adrenergic agonists analgesia sparing effect neutering |
| title | Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs |
| title_full | Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs |
| title_fullStr | Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs |
| title_full_unstemmed | Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs |
| title_short | Total intravenous anesthesia with propofol, ketamine, and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs |
| title_sort | total intravenous anesthesia with propofol ketamine and lidocaine associated with dexmedetomidine or xylazine for ovariohysterectomy surgery in female dogs |
| topic | infusion rate alpha-2 adrenergic agonists analgesia sparing effect neutering |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782024000600601&lng=en&tlng=en |
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