The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery
Background: Increased intracranial pressure (ICP) can be life-threatening and is associated with poor prognosis. In these patients, mortality rate and life expectancy would increase by reducing the intracranial pressure. Finding appropriate way to reduce pressure without specific changes in blood el...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2016-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/5666 |
| _version_ | 1797759693882392576 |
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| author | Mohammad Ali Attari Gholam Reza Khalili Amir Taheri |
| author_facet | Mohammad Ali Attari Gholam Reza Khalili Amir Taheri |
| author_sort | Mohammad Ali Attari |
| collection | DOAJ |
| description | Background: Increased intracranial pressure (ICP) can be life-threatening and is associated with poor prognosis. In these patients, mortality rate and life expectancy would increase by reducing the intracranial pressure. Finding appropriate way to reduce pressure without specific changes in blood electrolytes and blood pressure is essential. This study aimed to evaluate the effect of rehydration with hypertonic saline 5% on intraoperative complications and prognosis in patients with high intracranial pressure.
Methods: This study was performed on 90 patients with high intracranial pressure undergone surgery. After skin incision, hypertonic saline 5% was injected intravenously. Electrolytes and vital signs of patients at baseline and at 24 and 48 hours after the surgery were compared. The data were analyzed using ANOVA with repeated measures test.
Findings: 54 patients (60%) were men and 36 (40%) were women, with the mean age of 48.1 ± 9.8 years. Administration of hypertonic saline significantly increased sodium level (137.5 to 144.9 mmol/l), potassium level (3.8 to 4.96 mmol/l), the amount of output (1.43 to 3.94 l), systolic blood pressure (104.6 to 127.32 mmHg), diastolic blood pressure (61.58 to 85.13 mmHg) and anion gap (9.34 to 18.8) (P < 0.001 for all).
Conclusion: This study showed that the use of hypertonic saline 5% serum in patients with high intracranial pressure who need surgery, improve the electrolyte and vital signs, especially blood pressure, which increases the quality of treatment and consequently reduces mortality rate of the patients. |
| first_indexed | 2024-03-12T18:48:05Z |
| format | Article |
| id | doaj.art-dbbed415578043e6aecaf2036670ea2c |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T18:48:05Z |
| publishDate | 2016-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-dbbed415578043e6aecaf2036670ea2c2023-08-02T07:30:57ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2016-03-0133367239323992128The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the SurgeryMohammad Ali Attari0Gholam Reza Khalili1Amir Taheri2Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranBackground: Increased intracranial pressure (ICP) can be life-threatening and is associated with poor prognosis. In these patients, mortality rate and life expectancy would increase by reducing the intracranial pressure. Finding appropriate way to reduce pressure without specific changes in blood electrolytes and blood pressure is essential. This study aimed to evaluate the effect of rehydration with hypertonic saline 5% on intraoperative complications and prognosis in patients with high intracranial pressure. Methods: This study was performed on 90 patients with high intracranial pressure undergone surgery. After skin incision, hypertonic saline 5% was injected intravenously. Electrolytes and vital signs of patients at baseline and at 24 and 48 hours after the surgery were compared. The data were analyzed using ANOVA with repeated measures test. Findings: 54 patients (60%) were men and 36 (40%) were women, with the mean age of 48.1 ± 9.8 years. Administration of hypertonic saline significantly increased sodium level (137.5 to 144.9 mmol/l), potassium level (3.8 to 4.96 mmol/l), the amount of output (1.43 to 3.94 l), systolic blood pressure (104.6 to 127.32 mmHg), diastolic blood pressure (61.58 to 85.13 mmHg) and anion gap (9.34 to 18.8) (P < 0.001 for all). Conclusion: This study showed that the use of hypertonic saline 5% serum in patients with high intracranial pressure who need surgery, improve the electrolyte and vital signs, especially blood pressure, which increases the quality of treatment and consequently reduces mortality rate of the patients.http://jims.mui.ac.ir/index.php/jims/article/view/5666Intracranial pressureHypertonic salinePrognosis |
| spellingShingle | Mohammad Ali Attari Gholam Reza Khalili Amir Taheri The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery مجله دانشکده پزشکی اصفهان Intracranial pressure Hypertonic saline Prognosis |
| title | The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery |
| title_full | The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery |
| title_fullStr | The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery |
| title_full_unstemmed | The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery |
| title_short | The Effect of Intravenous Therapy with Hypertonic Saline 5% (HTS) in Patients with High Intracranial Pressure, 24 and 48 Hours after the Surgery |
| title_sort | effect of intravenous therapy with hypertonic saline 5 hts in patients with high intracranial pressure 24 and 48 hours after the surgery |
| topic | Intracranial pressure Hypertonic saline Prognosis |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/5666 |
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