The role of kaempferol in gynaecological malignancies: progress and perspectives
Kaempferol, a flavonoid derived from various herbs such as cocoyam, propolis, and grapefruit, has garnered interest due to its numerous pharmacological benefits, including anti-inflammatory, antioxidant, and anti-diabetic properties. Kaempferol has been shown to possess notable anti-tumour bioactivi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1310416/full |
| _version_ | 1797400824978079744 |
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| author | Xijun Ma Xiaoyu Zhang Xuan Wang Congan Wang Yuning Ma |
| author_facet | Xijun Ma Xiaoyu Zhang Xuan Wang Congan Wang Yuning Ma |
| author_sort | Xijun Ma |
| collection | DOAJ |
| description | Kaempferol, a flavonoid derived from various herbs such as cocoyam, propolis, and grapefruit, has garnered interest due to its numerous pharmacological benefits, including anti-inflammatory, antioxidant, and anti-diabetic properties. Kaempferol has been shown to possess notable anti-tumour bioactivity, indicating potential for treating gynaecological malignancies. To date, numerous studies have demonstrated the potential of kaempferol to induce tumour cell apoptosis, inhibit proliferation, and prevent metastasis and invasion in several gynaecological malignancies, including breast, ovarian and endometrial cancers. However, there is currently insufficient research investigating the efficacy of kaempferol for the treatment of gynaecological malignancies, and a lack of systematic review of its mechanism of action. Therefore, this review is founded on a literature analysis of the anticancer effects of kaempferol on gynaecological malignancies. The goal is to provide valuable reference material for scientific researchers and medical practitioners. |
| first_indexed | 2024-03-09T02:01:13Z |
| format | Article |
| id | doaj.art-dbc43bd06b6a47ab95ab2a94cadb3493 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T02:01:13Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-dbc43bd06b6a47ab95ab2a94cadb34932023-12-08T05:13:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.13104161310416The role of kaempferol in gynaecological malignancies: progress and perspectivesXijun Ma0Xiaoyu Zhang1Xuan Wang2Congan Wang3Yuning Ma4Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Jinan, ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Jinan, ChinaNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Jinan, ChinaKey Laboratory of New Material Research Institute, Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKaempferol, a flavonoid derived from various herbs such as cocoyam, propolis, and grapefruit, has garnered interest due to its numerous pharmacological benefits, including anti-inflammatory, antioxidant, and anti-diabetic properties. Kaempferol has been shown to possess notable anti-tumour bioactivity, indicating potential for treating gynaecological malignancies. To date, numerous studies have demonstrated the potential of kaempferol to induce tumour cell apoptosis, inhibit proliferation, and prevent metastasis and invasion in several gynaecological malignancies, including breast, ovarian and endometrial cancers. However, there is currently insufficient research investigating the efficacy of kaempferol for the treatment of gynaecological malignancies, and a lack of systematic review of its mechanism of action. Therefore, this review is founded on a literature analysis of the anticancer effects of kaempferol on gynaecological malignancies. The goal is to provide valuable reference material for scientific researchers and medical practitioners.https://www.frontiersin.org/articles/10.3389/fphar.2023.1310416/fullkaempferolgynecologic malignant tumormechanismpathwaycancer |
| spellingShingle | Xijun Ma Xiaoyu Zhang Xuan Wang Congan Wang Yuning Ma The role of kaempferol in gynaecological malignancies: progress and perspectives Frontiers in Pharmacology kaempferol gynecologic malignant tumor mechanism pathway cancer |
| title | The role of kaempferol in gynaecological malignancies: progress and perspectives |
| title_full | The role of kaempferol in gynaecological malignancies: progress and perspectives |
| title_fullStr | The role of kaempferol in gynaecological malignancies: progress and perspectives |
| title_full_unstemmed | The role of kaempferol in gynaecological malignancies: progress and perspectives |
| title_short | The role of kaempferol in gynaecological malignancies: progress and perspectives |
| title_sort | role of kaempferol in gynaecological malignancies progress and perspectives |
| topic | kaempferol gynecologic malignant tumor mechanism pathway cancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1310416/full |
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