Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study
Chunlei Wu, Denhua Ma, Yu Chen Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of ChinaCorrespondence: Yu Chen People’s Republic of ChinaEmail chenyu5835@126.comPurpose: Here, we sought to determine the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-10-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-of-pulse-pressure-difference-and-diabetes-mellitus-in-chin-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818719097606635520 |
|---|---|
| author | Wu C Ma D Chen Y |
| author_facet | Wu C Ma D Chen Y |
| author_sort | Wu C |
| collection | DOAJ |
| description | Chunlei Wu, Denhua Ma, Yu Chen Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of ChinaCorrespondence: Yu Chen People’s Republic of ChinaEmail chenyu5835@126.comPurpose: Here, we sought to determine the association between pulse pressure difference and the incidence of type 2 diabetes mellitus (T2DM) in Chinese people.Methods: This study involved 211,814 participants among whom 4156 had been diagnosed with T2DM. The correlation between pulse pressure difference and T2DM incidence in Chinese people was determined by multivariate analysis. A smooth curve fitting diagram was then used to explore correlation between pulse pressure difference and T2DM incidence. Finally, the inflection point in the correlation between pulse pressure difference and the T2DM incidence was located by piecewise linear regression.Results: To understand the relationship, adjustments were made for sex, age, total serum cholesterol (TC), fasting blood glucose (FPG), triglyceride (TG), alanine aminotransferase (ALT), family history of diabetes, body mass index (BMI), blood urea nitrogen (BUN), drinking status, and smoking status. Diabetes incidence increased by 0.3% [HR 1.003 (1.001, 1.005), p = < 0.05] for every 1mmHg increase in pulse pressure difference. Smooth curve analysis showed that, when pulse pressure difference was ≤ 35mmHg, diabetes incidence negatively correlated to pulse pressure difference [HR 0.972 (0.953, 0.972) p = 0.053]. However, when pulse pressure difference was > 35mmHg, diabetes incidence increased with increasing pulse pressure difference [HR 1.044 (1.042, 1.047) p = < 0.001]. And between pulse pressure difference and fasting blood glucose in the final visit, the blood glucose level increased with the elevation of pulse pressure.Conclusion: The risk of diabetes was lowest at about 35mmHg pulse pressure difference.Keywords: pulse pressure difference, diabetes mellitus incidence, Chinese population, cohort study |
| first_indexed | 2024-12-17T20:01:32Z |
| format | Article |
| id | doaj.art-dbc7e8cb70114ffb9c8599ac03d7ce49 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-17T20:01:32Z |
| publishDate | 2021-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-dbc7e8cb70114ffb9c8599ac03d7ce492022-12-21T21:34:28ZengDove Medical PressInternational Journal of General Medicine1178-70742021-10-01Volume 146601660869640Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort StudyWu CMa DChen YChunlei Wu, Denhua Ma, Yu Chen Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of ChinaCorrespondence: Yu Chen People’s Republic of ChinaEmail chenyu5835@126.comPurpose: Here, we sought to determine the association between pulse pressure difference and the incidence of type 2 diabetes mellitus (T2DM) in Chinese people.Methods: This study involved 211,814 participants among whom 4156 had been diagnosed with T2DM. The correlation between pulse pressure difference and T2DM incidence in Chinese people was determined by multivariate analysis. A smooth curve fitting diagram was then used to explore correlation between pulse pressure difference and T2DM incidence. Finally, the inflection point in the correlation between pulse pressure difference and the T2DM incidence was located by piecewise linear regression.Results: To understand the relationship, adjustments were made for sex, age, total serum cholesterol (TC), fasting blood glucose (FPG), triglyceride (TG), alanine aminotransferase (ALT), family history of diabetes, body mass index (BMI), blood urea nitrogen (BUN), drinking status, and smoking status. Diabetes incidence increased by 0.3% [HR 1.003 (1.001, 1.005), p = < 0.05] for every 1mmHg increase in pulse pressure difference. Smooth curve analysis showed that, when pulse pressure difference was ≤ 35mmHg, diabetes incidence negatively correlated to pulse pressure difference [HR 0.972 (0.953, 0.972) p = 0.053]. However, when pulse pressure difference was > 35mmHg, diabetes incidence increased with increasing pulse pressure difference [HR 1.044 (1.042, 1.047) p = < 0.001]. And between pulse pressure difference and fasting blood glucose in the final visit, the blood glucose level increased with the elevation of pulse pressure.Conclusion: The risk of diabetes was lowest at about 35mmHg pulse pressure difference.Keywords: pulse pressure difference, diabetes mellitus incidence, Chinese population, cohort studyhttps://www.dovepress.com/association-of-pulse-pressure-difference-and-diabetes-mellitus-in-chin-peer-reviewed-fulltext-article-IJGMpulse pressure differencediabetes mellitus incidencechinese populationcohort |
| spellingShingle | Wu C Ma D Chen Y Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study International Journal of General Medicine pulse pressure difference diabetes mellitus incidence chinese population cohort |
| title | Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study |
| title_full | Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study |
| title_fullStr | Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study |
| title_full_unstemmed | Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study |
| title_short | Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study |
| title_sort | association of pulse pressure difference and diabetes mellitus in chinese people a cohort study |
| topic | pulse pressure difference diabetes mellitus incidence chinese population cohort |
| url | https://www.dovepress.com/association-of-pulse-pressure-difference-and-diabetes-mellitus-in-chin-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT wuc associationofpulsepressuredifferenceanddiabetesmellitusinchinesepeopleacohortstudy AT mad associationofpulsepressuredifferenceanddiabetesmellitusinchinesepeopleacohortstudy AT cheny associationofpulsepressuredifferenceanddiabetesmellitusinchinesepeopleacohortstudy |