Rhizoma coptidis: A potential cardiovascular protective agent
Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality in both the developed and developing world. Rhizoma coptidis (RC), known as Huang Lian in China, is the dried rhizome of medicinal plants from the family Ranunculaceae, such as Coptis chinensis Franch, C. deltoide...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00362/full |
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| author | Hui-Li Tan Hui-Li Tan Kok Gan Chan Priyia Pusparajah Acharaporn Duangjai Acharaporn Duangjai Surasak Saokaew Surasak Saokaew Surasak Saokaew Learn-Han Lee Learn-Han Lee Bey Hing Goh Bey Hing Goh |
| author_facet | Hui-Li Tan Hui-Li Tan Kok Gan Chan Priyia Pusparajah Acharaporn Duangjai Acharaporn Duangjai Surasak Saokaew Surasak Saokaew Surasak Saokaew Learn-Han Lee Learn-Han Lee Bey Hing Goh Bey Hing Goh |
| author_sort | Hui-Li Tan |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality in both the developed and developing world. Rhizoma coptidis (RC), known as Huang Lian in China, is the dried rhizome of medicinal plants from the family Ranunculaceae, such as Coptis chinensis Franch, C. deltoidea C.Y. Cheng et Hsiao, and C. teeta Wall which has been used by Chinese medicinal physicians for more than 2000 years. In China, RC is a common component in traditional medicines used to treat CVD associated problems including obesity, diabetes mellitus, hyperlipidemia, hyperglycemia and disorders of lipid metabolism. In recent years, numerous scientific studies have sought to investigate the biological properties of RC to provide scientific evidence for its traditional medical uses. RC has been found to exert significant beneficial effects on major risk factors for CVDs including anti-atherosclerotic effect, protection from myocardial ischemia-reperfusion injury, lipid-lowering effect, anti-obesity effect and anti-hepatic steatosis effect. These properties have been attributed to the presence of bioactive compounds contained in RC such as berberine, coptisine, palmatine, epiberberine, jatrorrhizine and magnoflorine; all of which have been demonstrated to have cardioprotective effects on the various parameters contributing to the occurrence of CVD through a variety of pathways. The evidence available in the published literature indicates that RC is a herb with tremendous potential to reduce the risks of CVDs, and this review aims to summarize the cardioprotective properties of RC with reference to the published literature which overall indicates that RC is a herb with remarkable potential to reduce the risks of CVDs. |
| first_indexed | 2024-12-23T19:52:39Z |
| format | Article |
| id | doaj.art-dbc81888d1e4424482d98d903bfd0d04 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-23T19:52:39Z |
| publishDate | 2016-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-dbc81888d1e4424482d98d903bfd0d042022-12-21T17:33:20ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122016-10-01710.3389/fphar.2016.00362223709Rhizoma coptidis: A potential cardiovascular protective agentHui-Li Tan0Hui-Li Tan1Kok Gan Chan2Priyia Pusparajah3Acharaporn Duangjai4Acharaporn Duangjai5Surasak Saokaew6Surasak Saokaew7Surasak Saokaew8Learn-Han Lee9Learn-Han Lee10Bey Hing Goh11Bey Hing Goh12Monash University, MalaysiaMonash University MalaysiaUniversity of MalayaMonash University MalaysiaUniversity of PhayaoUniversity of PhayaoMonash University, MalaysiaUniversity of PhayaoNaresuan UniversityMonash University, MalaysiaUniversity of PhayaoMonash University, MalaysiaUniversity of PhayaoCardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality in both the developed and developing world. Rhizoma coptidis (RC), known as Huang Lian in China, is the dried rhizome of medicinal plants from the family Ranunculaceae, such as Coptis chinensis Franch, C. deltoidea C.Y. Cheng et Hsiao, and C. teeta Wall which has been used by Chinese medicinal physicians for more than 2000 years. In China, RC is a common component in traditional medicines used to treat CVD associated problems including obesity, diabetes mellitus, hyperlipidemia, hyperglycemia and disorders of lipid metabolism. In recent years, numerous scientific studies have sought to investigate the biological properties of RC to provide scientific evidence for its traditional medical uses. RC has been found to exert significant beneficial effects on major risk factors for CVDs including anti-atherosclerotic effect, protection from myocardial ischemia-reperfusion injury, lipid-lowering effect, anti-obesity effect and anti-hepatic steatosis effect. These properties have been attributed to the presence of bioactive compounds contained in RC such as berberine, coptisine, palmatine, epiberberine, jatrorrhizine and magnoflorine; all of which have been demonstrated to have cardioprotective effects on the various parameters contributing to the occurrence of CVD through a variety of pathways. The evidence available in the published literature indicates that RC is a herb with tremendous potential to reduce the risks of CVDs, and this review aims to summarize the cardioprotective properties of RC with reference to the published literature which overall indicates that RC is a herb with remarkable potential to reduce the risks of CVDs.http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00362/fullCardiovascular DiseasesEthnopharmacologyCoptis chinensis FranchHuang LianCoptis root |
| spellingShingle | Hui-Li Tan Hui-Li Tan Kok Gan Chan Priyia Pusparajah Acharaporn Duangjai Acharaporn Duangjai Surasak Saokaew Surasak Saokaew Surasak Saokaew Learn-Han Lee Learn-Han Lee Bey Hing Goh Bey Hing Goh Rhizoma coptidis: A potential cardiovascular protective agent Frontiers in Pharmacology Cardiovascular Diseases Ethnopharmacology Coptis chinensis Franch Huang Lian Coptis root |
| title | Rhizoma coptidis: A potential cardiovascular protective agent |
| title_full | Rhizoma coptidis: A potential cardiovascular protective agent |
| title_fullStr | Rhizoma coptidis: A potential cardiovascular protective agent |
| title_full_unstemmed | Rhizoma coptidis: A potential cardiovascular protective agent |
| title_short | Rhizoma coptidis: A potential cardiovascular protective agent |
| title_sort | rhizoma coptidis a potential cardiovascular protective agent |
| topic | Cardiovascular Diseases Ethnopharmacology Coptis chinensis Franch Huang Lian Coptis root |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00362/full |
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