Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish
Abstract Esketamine (EK) has been widely used in the treatment of depression, but the effects of EK prenatal treatment on embryonic heart development have been rarely reported. This study assesses the effects of varying concentrations of EK on embryonic development and cardiogenesis to determine the...
المؤلفون الرئيسيون: | Shuang Li, Xiang Li, Rui Zhao, Tingyu Jiang, Qiuyun Ou, Huansen Huang, Jiancheng Tang |
---|---|
التنسيق: | مقال |
اللغة: | English |
منشور في: |
Nature Portfolio
2025-02-01
|
سلاسل: | Scientific Reports |
الوصول للمادة أونلاين: | https://doi.org/10.1038/s41598-025-91315-2 |
مواد مشابهة
-
Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos.
حسب: Chi-Tang Tu, وآخرون
منشور في: (2009-01-01) -
Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish
حسب: Yanyi Sun, وآخرون
منشور في: (2017-10-01) -
Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
حسب: Daniel R Carter, وآخرون
منشور في: (2014-01-01) -
GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
حسب: Brewer, A, وآخرون
منشور في: (2005) -
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
حسب: Jenny Schlesinger, وآخرون
منشور في: (2011-02-01)