Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish
Abstract Esketamine (EK) has been widely used in the treatment of depression, but the effects of EK prenatal treatment on embryonic heart development have been rarely reported. This study assesses the effects of varying concentrations of EK on embryonic development and cardiogenesis to determine the...
Hlavní autoři: | Shuang Li, Xiang Li, Rui Zhao, Tingyu Jiang, Qiuyun Ou, Huansen Huang, Jiancheng Tang |
---|---|
Médium: | Článek |
Jazyk: | English |
Vydáno: |
Nature Portfolio
2025-02-01
|
Edice: | Scientific Reports |
On-line přístup: | https://doi.org/10.1038/s41598-025-91315-2 |
Podobné jednotky
-
Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish
Autor: Yanyi Sun, a další
Vydáno: (2017-10-01) -
GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
Autor: Brewer, A, a další
Vydáno: (2005) -
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
Autor: Jenny Schlesinger, a další
Vydáno: (2011-02-01) -
nkx2.7 transcription factor is involved in zebrafish cardiac development
Autor: Simoes, A, a další
Vydáno: (2007) -
Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae
Autor: Shuo Huang, a další
Vydáno: (2024-06-01)