Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish
Abstract Esketamine (EK) has been widely used in the treatment of depression, but the effects of EK prenatal treatment on embryonic heart development have been rarely reported. This study assesses the effects of varying concentrations of EK on embryonic development and cardiogenesis to determine the...
Κύριοι συγγραφείς: | Shuang Li, Xiang Li, Rui Zhao, Tingyu Jiang, Qiuyun Ou, Huansen Huang, Jiancheng Tang |
---|---|
Μορφή: | Άρθρο |
Γλώσσα: | English |
Έκδοση: |
Nature Portfolio
2025-02-01
|
Σειρά: | Scientific Reports |
Διαθέσιμο Online: | https://doi.org/10.1038/s41598-025-91315-2 |
Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
-
Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos.
ανά: Chi-Tang Tu, κ.ά.
Έκδοση: (2009-01-01) -
Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish
ανά: Yanyi Sun, κ.ά.
Έκδοση: (2017-10-01) -
Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
ανά: Daniel R Carter, κ.ά.
Έκδοση: (2014-01-01) -
GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
ανά: Brewer, A, κ.ά.
Έκδοση: (2005) -
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
ανά: Jenny Schlesinger, κ.ά.
Έκδοση: (2011-02-01)