Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish

Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish

Abstract Esketamine (EK) has been widely used in the treatment of depression, but the effects of EK prenatal treatment on embryonic heart development have been rarely reported. This study assesses the effects of varying concentrations of EK on embryonic development and cardiogenesis to determine the...

Полное описание

Библиографические подробности
Главные авторы:	Shuang Li, Xiang Li, Rui Zhao, Tingyu Jiang, Qiuyun Ou, Huansen Huang, Jiancheng Tang
Формат:	Статья
Язык:	English
Опубликовано:	Nature Portfolio 2025-02-01
Серии:	Scientific Reports
Online-ссылка:	https://doi.org/10.1038/s41598-025-91315-2

Схожие документы

Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos.
по: Chi-Tang Tu, и др.
Опубликовано: (2009-01-01)

Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish
по: Yanyi Sun, и др.
Опубликовано: (2017-10-01)

Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
по: Daniel R Carter, и др.
Опубликовано: (2014-01-01)

GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
по: Brewer, A, и др.
Опубликовано: (2005)

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
по: Jenny Schlesinger, и др.
Опубликовано: (2011-02-01)

nkx2.7 transcription factor is involved in zebrafish cardiac development
по: Simoes, A, и др.
Опубликовано: (2007)

Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae
по: Shuo Huang, и др.
Опубликовано: (2024-06-01)

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases
по: Ce Cao, и др.
Опубликовано: (2023-12-01)

Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd.
по: Lei Zhou, и др.
Опубликовано: (2012-01-01)

Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene
по: Christiane Fuchs, и др.
Опубликовано: (2016-02-01)

NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.
по: Ali M Riazi, и др.
Опубликовано: (2009-05-01)

Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
по: Eun Young Kim, и др.
Опубликовано: (2011-01-01)

Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
по: Mikael Jumppanen, и др.
Опубликовано: (2024-04-01)

GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation.
по: Peterkin, T, и др.
Опубликовано: (2003)

Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
по: Peter G. Farlie, и др.
Опубликовано: (2017-07-01)

The broad role of Nkx3.2 in the development of the zebrafish axial skeleton.
по: Laura Waldmann, и др.
Опубликовано: (2021-01-01)

nkx2.1 and nkx2.4 genes function partially redundant during development of the zebrafish hypothalamus, preoptic region, and pallidum
по: Wolfgang eDriever, и др.
Опубликовано: (2014-12-01)

Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts
по: Leyre López-Muneta, и др.
Опубликовано: (2022-01-01)

Cardiac transcription factor Nkx2.5 is downregulated under excessive O-GlcNAcylation condition.
по: Hoe Suk Kim, и др.
Опубликовано: (2012-01-01)

Non‐invasive lung cancer diagnosis by detection of GATA6 and NKX2‐1 isoforms in exhaled breath condensate
по: Aditi Mehta, и др.
Опубликовано: (2016-11-01)

BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish.
по: Linwei Li, и др.
Опубликовано: (2019-02-01)

Analysis of genetic polymorphisms of TBX5, NKX2-5 and GATA4 cardiac transcription factor genes in Malaysian non syndromic congenital heart disease subjects
по: Khadhim, Nora F.
Опубликовано: (2012)

Prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation
по: Wen-Hui Xie, и др.
Опубликовано: (2013-06-01)

Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish
по: Kendall E Martin, и др.
Опубликовано: (2023-05-01)

The impact of esketamine on cardiac function in patients undergoing anesthesia
по: Edward Sun, и др.
Опубликовано: (2025-03-01)

Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish
по: Oscar A. Peña, и др.
Опубликовано: (2021-09-01)

Association of NFKB1, NKX2-5, GATA4 and RANKL gene polymorphisms with sporadic congenital heart disease in Greek patients
по: Aidinidou L, и др.
Опубликовано: (2021-07-01)

Activation of Nkx2.5 transcriptional program is required for adult myocardial repair
по: Carmen de Sena-Tomás, и др.
Опубликовано: (2022-05-01)

Nkx2.5 Based Ventricular Programming of Murine ESC-Derived Cardiomyocytes
по: Frauke Thiele, и др.
Опубликовано: (2019-08-01)

Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer.
по: Stefanie A Doppler, и др.
Опубликовано: (2014-01-01)

Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1
по: Songwei Wang, и др.
Опубликовано: (2024-09-01)

The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus.
по: Bryan E Luu, и др.
Опубликовано: (2015-01-01)

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.
по: Risebro, C, и др.
Опубликовано: (2012)

Generation of a human embryonic stem cell line (SKLRMe004-A) carrying NKX2.5-EGFP and TBX5-Tdtomato dual fluorescent reporters
по: Zhazheng He, и др.
Опубликовано: (2023-03-01)

Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta
по: Lyad Zamir, и др.
Опубликовано: (2017-03-01)

NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells
по: Ricardo Cortez Cardoso Penha, и др.
Опубликовано: (2018-05-01)

Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility
по: Cheng Kai-Chun, и др.
Опубликовано: (2011-06-01)

Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5
по: Costa, M, и др.
Опубликовано: (2011)

Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation
по: Wenyu Hu, и др.
Опубликовано: (2021-02-01)

Embryonic malformations in an offspring of the shortnose guitarfish
по: Natascha Wosnick, и др.
Опубликовано: (2019-10-01)