Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish

Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish

Abstract Esketamine (EK) has been widely used in the treatment of depression, but the effects of EK prenatal treatment on embryonic heart development have been rarely reported. This study assesses the effects of varying concentrations of EK on embryonic development and cardiogenesis to determine the...

书目详细资料
Main Authors:	Shuang Li, Xiang Li, Rui Zhao, Tingyu Jiang, Qiuyun Ou, Huansen Huang, Jiancheng Tang
格式:	文件
语言:	English
出版:	Nature Portfolio 2025-02-01
丛编:	Scientific Reports
在线阅读:	https://doi.org/10.1038/s41598-025-91315-2

相似书籍

Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish
由: Yanyi Sun, et al.
出版: (2017-10-01)

GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
由: Brewer, A, et al.
出版: (2005)

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
由: Jenny Schlesinger, et al.
出版: (2011-02-01)

nkx2.7 transcription factor is involved in zebrafish cardiac development
由: Simoes, A, et al.
出版: (2007)

Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae
由: Shuo Huang, et al.
出版: (2024-06-01)

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases
由: Ce Cao, et al.
出版: (2023-12-01)

Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd.
由: Lei Zhou, et al.
出版: (2012-01-01)

Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene
由: Christiane Fuchs, et al.
出版: (2016-02-01)

Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
由: Eun Young Kim, et al.
出版: (2011-01-01)

Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
由: Mikael Jumppanen, et al.
出版: (2024-04-01)

GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation.
由: Peterkin, T, et al.
出版: (2003)

Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing
由: Peter G. Farlie, et al.
出版: (2017-07-01)

Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts
由: Leyre López-Muneta, et al.
出版: (2022-01-01)

Non‐invasive lung cancer diagnosis by detection of GATA6 and NKX2‐1 isoforms in exhaled breath condensate
由: Aditi Mehta, et al.
出版: (2016-11-01)

BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish.
由: Linwei Li, et al.
出版: (2019-02-01)

Analysis of genetic polymorphisms of TBX5, NKX2-5 and GATA4 cardiac transcription factor genes in Malaysian non syndromic congenital heart disease subjects
由: Khadhim, Nora F.
出版: (2012)

Prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation
由: Wen-Hui Xie, et al.
出版: (2013-06-01)

Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish
由: Kendall E Martin, et al.
出版: (2023-05-01)

Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish
由: Oscar A. Peña, et al.
出版: (2021-09-01)

Association of NFKB1, NKX2-5, GATA4 and RANKL gene polymorphisms with sporadic congenital heart disease in Greek patients
由: Aidinidou L, et al.
出版: (2021-07-01)

Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1
由: Songwei Wang, et al.
出版: (2024-09-01)

Activation of Nkx2.5 transcriptional program is required for adult myocardial repair
由: Carmen de Sena-Tomás, et al.
出版: (2022-05-01)

Nkx2.5 Based Ventricular Programming of Murine ESC-Derived Cardiomyocytes
由: Frauke Thiele, et al.
出版: (2019-08-01)

Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer.
由: Stefanie A Doppler, et al.
出版: (2014-01-01)

The impact of esketamine on cardiac function in patients undergoing anesthesia
由: Edward Sun, et al.
出版: (2025-03-01)

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.
由: Risebro, C, et al.
出版: (2012)

Generation of a human embryonic stem cell line (SKLRMe004-A) carrying NKX2.5-EGFP and TBX5-Tdtomato dual fluorescent reporters
由: Zhazheng He, et al.
出版: (2023-03-01)

Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta
由: Lyad Zamir, et al.
出版: (2017-03-01)

NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells
由: Ricardo Cortez Cardoso Penha, et al.
出版: (2018-05-01)

Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5
由: Costa, M, et al.
出版: (2011)

The Epicardium in the Embryonic and Adult Zebrafish
由: Marina Peralta, et al.
出版: (2014-04-01)

Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations.
由: Christina S Chao, et al.
出版: (2015-01-01)

Gata4, 5 or 6 are essential for heart and blood development in the zebrafish
由: Gibson, A, et al.
出版: (2005)

Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells
由: Callinice D. Capo-chichi, et al.
出版: (2010-01-01)

The generation and validation of a dual cardiac HAND1-Tomato NKX2-5-GFP human embryonic stem cell line UMANe002-A-3
由: A.T. Lynch, et al.
出版: (2024-06-01)

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche
由: Fitch, SR, et al.
出版: (2019)

Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response.
由: Jop H van Berlo, et al.
出版: (2013-01-01)

An assay for permeability of the zebrafish embryonic neuroepithelium
由: Chang, Jessica T., et al.
出版: (2014)

Characterization of embryonic globin genes of the zebrafish.
由: Brownlie, A, et al.
出版: (2003)

Bioenergetic profiling of zebrafish embryonic development.
由: Krista D Stackley, et al.
出版: (2011-01-01)