Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis
Several studies have reported the characteristics of Coronavirus disease 2019 (COVID-19), yet there is a gap in our understanding of the ocular manifestations of COVID-19. In this systematic review and meta-analysis, we investigated the prevalence of ocular manifestations in COVID-19 patients. We se...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2021-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | https://doi.org/10.18502/jovr.v16i1.8256 |
| _version_ | 1811325381126389760 |
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| author | Naser Nasiri Hamid Sharifi Azam Bazrafshan Atefeh Noori Mohammad Karamouzian Ali Sharifi |
| author_facet | Naser Nasiri Hamid Sharifi Azam Bazrafshan Atefeh Noori Mohammad Karamouzian Ali Sharifi |
| author_sort | Naser Nasiri |
| collection | DOAJ |
| description | Several studies have reported the characteristics of Coronavirus disease 2019 (COVID-19), yet there is a gap in our understanding of the ocular manifestations of COVID-19. In this systematic review and meta-analysis, we investigated the prevalence of ocular manifestations in COVID-19 patients. We searched Pubmed, Embase, Scopus, Web of Science, and medRxiv from December 1, 2019 to August 11, 2020. Two independent reviewers screened the articles, abstracted the data, and assessed the quality of included studies in duplicate. Thirty-eight studies were eligible after screening of 895 unique articles, with a total of 8,219 COVID-19 patients (55.3% female; n = 3,486 out of 6,308 patients). Using data extracted from cross-sectional studies, we performed random-effects meta-analyses to estimate the pooled prevalence of ocular symptoms along with 95% confidence interval (CI). The prevalence of ocular manifestations was estimated to be 11.03% (95% CI: 5.71–17.72). In the studies that reported the details of observed ocular symptoms, the most common ocular manifestations were dry eye or foreign body sensation (n = 138, 16%), redness (n = 114, 13.3%), tearing (n = 111, 12.8%), itching (n = 109, 12.6%), eye pain (n = 83, 9.6%) and discharge (n = 76, 8.8%). Moreover, conjunctivitis had the highest rate among reported ocular diseases in COVID-19 patients (79 out of 89, 88.8%). The results suggest that approximately one out of ten COVID-19 patients show at least one ocular symptom. Attention to ocular manifestations, especially conjunctivitis, can increase the sensitivity of COVID-19 detection among patients. |
| first_indexed | 2024-04-13T14:32:09Z |
| format | Article |
| id | doaj.art-dbc8cc93374e494eb6ad72ce9dea35b4 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-13T14:32:09Z |
| publishDate | 2021-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-dbc8cc93374e494eb6ad72ce9dea35b42022-12-22T02:43:09ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2021-01-011610311210.18502/jovr.v16i1.8256jovr.v16i1.8256Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysisNaser Nasiri0Hamid Sharifi1Azam Bazrafshan2Atefeh Noori3Mohammad Karamouzian4Ali Sharifi5 Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Department of Ophthalmology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, IranSeveral studies have reported the characteristics of Coronavirus disease 2019 (COVID-19), yet there is a gap in our understanding of the ocular manifestations of COVID-19. In this systematic review and meta-analysis, we investigated the prevalence of ocular manifestations in COVID-19 patients. We searched Pubmed, Embase, Scopus, Web of Science, and medRxiv from December 1, 2019 to August 11, 2020. Two independent reviewers screened the articles, abstracted the data, and assessed the quality of included studies in duplicate. Thirty-eight studies were eligible after screening of 895 unique articles, with a total of 8,219 COVID-19 patients (55.3% female; n = 3,486 out of 6,308 patients). Using data extracted from cross-sectional studies, we performed random-effects meta-analyses to estimate the pooled prevalence of ocular symptoms along with 95% confidence interval (CI). The prevalence of ocular manifestations was estimated to be 11.03% (95% CI: 5.71–17.72). In the studies that reported the details of observed ocular symptoms, the most common ocular manifestations were dry eye or foreign body sensation (n = 138, 16%), redness (n = 114, 13.3%), tearing (n = 111, 12.8%), itching (n = 109, 12.6%), eye pain (n = 83, 9.6%) and discharge (n = 76, 8.8%). Moreover, conjunctivitis had the highest rate among reported ocular diseases in COVID-19 patients (79 out of 89, 88.8%). The results suggest that approximately one out of ten COVID-19 patients show at least one ocular symptom. Attention to ocular manifestations, especially conjunctivitis, can increase the sensitivity of COVID-19 detection among patients.https://doi.org/10.18502/jovr.v16i1.8256conjunctivitiscovid-19meta-analysisocular manifestationssystematic review |
| spellingShingle | Naser Nasiri Hamid Sharifi Azam Bazrafshan Atefeh Noori Mohammad Karamouzian Ali Sharifi Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis Journal of Ophthalmic & Vision Research conjunctivitis covid-19 meta-analysis ocular manifestations systematic review |
| title | Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis |
| title_full | Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis |
| title_fullStr | Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis |
| title_short | Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis |
| title_sort | ocular manifestations of covid 19 a systematic review and meta analysis |
| topic | conjunctivitis covid-19 meta-analysis ocular manifestations systematic review |
| url | https://doi.org/10.18502/jovr.v16i1.8256 |
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