Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer’s Disease Pathology

Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer’s Disease Pathology

Traditional approaches to studying Alzheimer’s disease (AD) using mouse models and cell lines have advanced our understanding of AD pathogenesis. However, with the growing divide between model systems and clinical therapeutic outcomes, the limitations of these approaches are increasingly a...

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Bibliographic Details
Main Authors: Sean Schrank, John McDaid, Clark A. Briggs, Sarah Mustaly-Kalimi, Deanna Brinks, Aiden Houcek, Oded Singer, Virginie Bottero, Robert A. Marr, Grace E. Stutzmann
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
ipsc
alzheimer’s disease
amyloid
tau
calcium
fibroblast
human
il-18
ryanodine receptor
Online Access:https://www.mdpi.com/1422-0067/21/3/1030

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