Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized Forms
Applicability of modern immunomodulator Polyoxidonium for plague treatment was investigated. Inclusion of Polyoxidonium in the therapeutic scheme increased efficiency of treatment with antibiotics of experimental generalized plague in mice challenged with Yersinia pestis strain 231, the latter being...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2009-02-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/1007 |
| _version_ | 1811153564036235264 |
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| author | T. A. Bondareva A. Yu. Poyarkov E. Yu. Vakhnov |
| author_facet | T. A. Bondareva A. Yu. Poyarkov E. Yu. Vakhnov |
| author_sort | T. A. Bondareva |
| collection | DOAJ |
| description | Applicability of modern immunomodulator Polyoxidonium for plague treatment was investigated. Inclusion of Polyoxidonium in the therapeutic scheme increased efficiency of treatment with antibiotics of experimental generalized plague in mice challenged with Yersinia pestis strain 231, the latter being typical representative of continental variant of plague microbe. Life duration enhancement and increase of the number of survived animals challenged with plague agent were registered after prophylactic or emergency injection of Polyoxidonium against the background of treatment with antibiotic. |
| first_indexed | 2024-03-08T13:44:53Z |
| format | Article |
| id | doaj.art-dbcbb28737824f94b528b7a567f6ca6b |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:59:04Z |
| publishDate | 2009-02-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-dbcbb28737824f94b528b7a567f6ca6b2024-04-05T16:47:05ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2009-02-0101(99)676910.21055/0370-1069-2009-1(99)-67-69990Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized FormsT. A. Bondareva0A. Yu. Poyarkov1E. Yu. Vakhnov2Russian Ministry of Defense 48 Central Research Institute, KirovRussian Ministry of Defense 48 Central Research Institute, KirovRussian Ministry of Defense 48 Central Research Institute, KirovApplicability of modern immunomodulator Polyoxidonium for plague treatment was investigated. Inclusion of Polyoxidonium in the therapeutic scheme increased efficiency of treatment with antibiotics of experimental generalized plague in mice challenged with Yersinia pestis strain 231, the latter being typical representative of continental variant of plague microbe. Life duration enhancement and increase of the number of survived animals challenged with plague agent were registered after prophylactic or emergency injection of Polyoxidonium against the background of treatment with antibiotic.https://journal.microbe.ru/jour/article/view/1007plaguepolyoxidoniumimmunomodulatorsgeneralized form of infection |
| spellingShingle | T. A. Bondareva A. Yu. Poyarkov E. Yu. Vakhnov Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized Forms Проблемы особо опасных инфекций plague polyoxidonium immunomodulators generalized form of infection |
| title | Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized Forms |
| title_full | Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized Forms |
| title_fullStr | Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized Forms |
| title_full_unstemmed | Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized Forms |
| title_short | Application of Polyoxidonium in the Mixed Treatment of Experimental Plague Generalized Forms |
| title_sort | application of polyoxidonium in the mixed treatment of experimental plague generalized forms |
| topic | plague polyoxidonium immunomodulators generalized form of infection |
| url | https://journal.microbe.ru/jour/article/view/1007 |
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