Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

The structural polymorphism and the physiological and pathophysiological roles of two important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer’s disease (AD) are reviewed. Recent results demonstrate that monomeric Aβ has important physiological functions. Toxic oligomeric Aβ ass...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Botond Penke, Mária Szűcs, Ferenc Bogár
स्वरूप: लेख
भाषा:English
प्रकाशित: MDPI AG 2020-04-01
श्रृंखला:Molecules
विषय:
ऑनलाइन पहुंच:https://www.mdpi.com/1420-3049/25/7/1659