Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

The structural polymorphism and the physiological and pathophysiological roles of two important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer’s disease (AD) are reviewed. Recent results demonstrate that monomeric Aβ has important physiological functions. Toxic oligomeric Aβ ass...

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Bibliografiska uppgifter
Huvudupphovsmän: Botond Penke, Mária Szűcs, Ferenc Bogár
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2020-04-01
Serie:Molecules
Ämnen:
Alzheimer’s disease
amyloid β oligomers
tau oligomers
physiological actions
pathophysiology
amyloid formation
Länkar:https://www.mdpi.com/1420-3049/25/7/1659

Internet

https://www.mdpi.com/1420-3049/25/7/1659

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