Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & Adolescents
Introduction: India harbors highest number of tuberculosis (TB) patients globally. Few studies have focused on TB in young children who constitute a vulnerable population and lack of early diagnosis results in increased morbidity. Aim: To study the tuberculin reactivity in clinically suspected...
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| Format: | Article |
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JCDR Research and Publications Pvt. Ltd.
2016-10-01
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| Series: | National Journal of Laboratory Medicine |
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| Online Access: | http://www.njlm.net/articles/PDF/2181/18886_F(GH)_PF1(VsuGH)_PFA(NC)_PF2(VsuGH).pdf |
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| author | Santhosh Jose Mohamad Ismael K |
| author_facet | Santhosh Jose Mohamad Ismael K |
| author_sort | Santhosh Jose |
| collection | DOAJ |
| description | Introduction: India harbors highest number of tuberculosis
(TB) patients globally. Few studies have focused on TB in
young children who constitute a vulnerable population and lack
of early diagnosis results in increased morbidity.
Aim: To study the tuberculin reactivity in clinically suspected
cases of pulmonary tuberculosis in children and adolescents
attending Paediatrics OPD in a tertiary care centre and to
study the effect of nutritional status of children on tuberculin
reactivity.
Study design: Cross sectional study was conducted in
Department of Pediatrics of MES Medical college Hospital,
Perinthalmanna, for a period 1 year starting from 01/01/2013 to
31/12/2013. In all 1120 subjects were considered for the study
out of which 111 patients lost follow-up hence a final sample
size of 1009 was obtained.
Materials and Methods: Children aged between 1 to 18 years
with suspected TB were prospectively enrolled at a Tertiary
Hospital in Malappuram district, Kerala, India. Children were
specifically examined for BCG scar. Tuberculin testing was
done in all children using the purified protein derivative (PPD).
Results: Tuberculin reactivity among clinically suspected
cases of Pulmonary tuberculosis using 1TU PPDRT23 was
only 4.8 % as per our study which is in concordance with new
sputum positive /case detection rate in Malappuram district,
ie; 22-25 per lakh per year. Malnourished children had more
tuberculin reactivity than normal children in our study.
Conclusion: Tuberculin test has a sensitivity only of 4.8%
among all clinically suspected cases of tuberculosis, and
malnutrition and tuberculosis often co-exist and worsen each
other. |
| first_indexed | 2024-12-11T03:41:04Z |
| format | Article |
| id | doaj.art-dbcc6b0c1d944c4eb347d9e8e618576f |
| institution | Directory Open Access Journal |
| issn | 2277-8551 2455-6882 |
| language | English |
| last_indexed | 2024-12-11T03:41:04Z |
| publishDate | 2016-10-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | National Journal of Laboratory Medicine |
| spelling | doaj.art-dbcc6b0c1d944c4eb347d9e8e618576f2022-12-22T01:22:08ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822016-10-0154PO22PO2610.7860/NJLM/2016/18886:2181Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & AdolescentsSanthosh Jose0 Mohamad Ismael K1Associate Professor, Department of Paediatrics, MES Medical College, Perinthalmanna, Kerala University of Health Sciences, Kerala, India.Assistant Professor, Department of Paediatrics, MES Medical College, Perinthalmanna, Kerala University of Health Sciences, Kerala, India.Introduction: India harbors highest number of tuberculosis (TB) patients globally. Few studies have focused on TB in young children who constitute a vulnerable population and lack of early diagnosis results in increased morbidity. Aim: To study the tuberculin reactivity in clinically suspected cases of pulmonary tuberculosis in children and adolescents attending Paediatrics OPD in a tertiary care centre and to study the effect of nutritional status of children on tuberculin reactivity. Study design: Cross sectional study was conducted in Department of Pediatrics of MES Medical college Hospital, Perinthalmanna, for a period 1 year starting from 01/01/2013 to 31/12/2013. In all 1120 subjects were considered for the study out of which 111 patients lost follow-up hence a final sample size of 1009 was obtained. Materials and Methods: Children aged between 1 to 18 years with suspected TB were prospectively enrolled at a Tertiary Hospital in Malappuram district, Kerala, India. Children were specifically examined for BCG scar. Tuberculin testing was done in all children using the purified protein derivative (PPD). Results: Tuberculin reactivity among clinically suspected cases of Pulmonary tuberculosis using 1TU PPDRT23 was only 4.8 % as per our study which is in concordance with new sputum positive /case detection rate in Malappuram district, ie; 22-25 per lakh per year. Malnourished children had more tuberculin reactivity than normal children in our study. Conclusion: Tuberculin test has a sensitivity only of 4.8% among all clinically suspected cases of tuberculosis, and malnutrition and tuberculosis often co-exist and worsen each other.http://www.njlm.net/articles/PDF/2181/18886_F(GH)_PF1(VsuGH)_PFA(NC)_PF2(VsuGH).pdfmantoux testmid upperarm circumferenceweight for age |
| spellingShingle | Santhosh Jose Mohamad Ismael K Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & Adolescents National Journal of Laboratory Medicine mantoux test mid upperarm circumference weight for age |
| title | Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & Adolescents |
| title_full | Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & Adolescents |
| title_fullStr | Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & Adolescents |
| title_full_unstemmed | Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & Adolescents |
| title_short | Study of Tuberculin Reactivity in Clinically Suspected Cases of Pulmonary Tuberculosis in Children & Adolescents |
| title_sort | study of tuberculin reactivity in clinically suspected cases of pulmonary tuberculosis in children adolescents |
| topic | mantoux test mid upperarm circumference weight for age |
| url | http://www.njlm.net/articles/PDF/2181/18886_F(GH)_PF1(VsuGH)_PFA(NC)_PF2(VsuGH).pdf |
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