Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease
Abstract Introduction This study characterizes retinal capillary blood flow in subjects with autosomal dominant Alzheimer's disease (ADAD)‐causing mutations. Methods Carriers of PSEN1 or APP mutations were prospectively recruited and split into early‐stage (ES) and late‐stage (LS) groups. Contr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12162 |
| _version_ | 1797975552235143168 |
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| author | Maxwell B. Singer John M. Ringman Zhongdi Chu Xiao Zhou Xuejuan Jiang Anoush Shahidzadeh Ruikang K. Wang Amir H. Kashani |
| author_facet | Maxwell B. Singer John M. Ringman Zhongdi Chu Xiao Zhou Xuejuan Jiang Anoush Shahidzadeh Ruikang K. Wang Amir H. Kashani |
| author_sort | Maxwell B. Singer |
| collection | DOAJ |
| description | Abstract Introduction This study characterizes retinal capillary blood flow in subjects with autosomal dominant Alzheimer's disease (ADAD)‐causing mutations. Methods Carriers of PSEN1 or APP mutations were prospectively recruited and split into early‐stage (ES) and late‐stage (LS) groups. Controls were normal subjects and non‐carriers from the at‐risk group. Capillary blood flow was quantified using an optical coherence tomography angiography‐based measure of erythrocyte flux through capillary segments. Statistical analyses were adjusted for correlation between two eyes of the same subject. Results ES carriers had significantly greater capillary blood flow than controls and LS carriers. ES and LS carriers had significantly greater capillary blood flow heterogeneity than controls. There was no difference between capillary blood flow of LS carriers and controls. Discussion ES ADAD carriers demonstrate increased retinal capillary blood flow and flow heterogeneity compared to controls. These findings support the hypothesis that increased perfusion is a pathophysiologic feature of presymptomatic stages of ADAD. |
| first_indexed | 2024-04-11T04:37:22Z |
| format | Article |
| id | doaj.art-dbcd36cd3f084a2485e1ebd4b92674fa |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:37:22Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-dbcd36cd3f084a2485e1ebd4b92674fa2022-12-28T09:12:13ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12162Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's diseaseMaxwell B. Singer0John M. Ringman1Zhongdi Chu2Xiao Zhou3Xuejuan Jiang4Anoush Shahidzadeh5Ruikang K. Wang6Amir H. Kashani7Department of Ophthalmology USC Roski Eye Institute Keck School of Medicine of the University of Southern California Los Angeles California USADepartment of Neurology Keck School of Medicine of the University of Southern California Los Angeles California USADepartment of Bioengineering University of Washington Seattle Washington USADepartment of Bioengineering University of Washington Seattle Washington USADepartment of Ophthalmology USC Roski Eye Institute Keck School of Medicine of the University of Southern California Los Angeles California USADepartment of Ophthalmology USC Roski Eye Institute Keck School of Medicine of the University of Southern California Los Angeles California USADepartment of Bioengineering University of Washington Seattle Washington USADepartment of Ophthalmology USC Roski Eye Institute Keck School of Medicine of the University of Southern California Los Angeles California USAAbstract Introduction This study characterizes retinal capillary blood flow in subjects with autosomal dominant Alzheimer's disease (ADAD)‐causing mutations. Methods Carriers of PSEN1 or APP mutations were prospectively recruited and split into early‐stage (ES) and late‐stage (LS) groups. Controls were normal subjects and non‐carriers from the at‐risk group. Capillary blood flow was quantified using an optical coherence tomography angiography‐based measure of erythrocyte flux through capillary segments. Statistical analyses were adjusted for correlation between two eyes of the same subject. Results ES carriers had significantly greater capillary blood flow than controls and LS carriers. ES and LS carriers had significantly greater capillary blood flow heterogeneity than controls. There was no difference between capillary blood flow of LS carriers and controls. Discussion ES ADAD carriers demonstrate increased retinal capillary blood flow and flow heterogeneity compared to controls. These findings support the hypothesis that increased perfusion is a pathophysiologic feature of presymptomatic stages of ADAD.https://doi.org/10.1002/dad2.12162autosomal dominant Alzheimer's diseasebiomarkerscapillary blood flowLatinooptical coherence tomography angiographyretina |
| spellingShingle | Maxwell B. Singer John M. Ringman Zhongdi Chu Xiao Zhou Xuejuan Jiang Anoush Shahidzadeh Ruikang K. Wang Amir H. Kashani Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring autosomal dominant Alzheimer's disease biomarkers capillary blood flow Latino optical coherence tomography angiography retina |
| title | Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease |
| title_full | Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease |
| title_fullStr | Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease |
| title_full_unstemmed | Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease |
| title_short | Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease |
| title_sort | abnormal retinal capillary blood flow in autosomal dominant alzheimer s disease |
| topic | autosomal dominant Alzheimer's disease biomarkers capillary blood flow Latino optical coherence tomography angiography retina |
| url | https://doi.org/10.1002/dad2.12162 |
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