Deciphering the mechanism of action of VP343, an antileishmanial drug candidate, in Leishmania infantum

Summary: Antileishmanial chemotherapy is currently limited due to severe toxic side effects and drug resistance. Hence, new antileishmanial compounds based on alternative approaches, mainly to avoid the emergence of drug resistance, are needed. The present work aims to decipher the mechanism of acti...

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Hlavní autoři: Sameh Obeid, Eloisa Berbel-Manaia, Valérie Nicolas, Indira Dennemont, Julien Barbier, Jean-Christophe Cintrat, Daniel Gillet, Philippe M. Loiseau, Sébastien Pomel
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2023-11-01
Edice:iScience
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On-line přístup:http://www.sciencedirect.com/science/article/pii/S2589004223022216