Skeletal muscle dysfunction in chronic obstructive pulmonary disease
<p>Abstract</p> <p>It has become increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Muscle strength and endurance are decreased, whereas muscle fatigability is increased. There is a reduced proportion of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2001-05-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/rr60 |
| _version_ | 1818753884037840896 |
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| author | Bozkanat Erkan Jeffery Mador M |
| author_facet | Bozkanat Erkan Jeffery Mador M |
| author_sort | Bozkanat Erkan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>It has become increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Muscle strength and endurance are decreased, whereas muscle fatigability is increased. There is a reduced proportion of type I fibers and an increase in type II fibers. Muscle atrophy occurs with a reduction in fiber cross-sectional area. Oxidative enzyme activity is decreased, and measurement of muscle bioenergetics during exercise reveals a reduced aerobic capacity. Deconditioning is probably very important mechanistically. Other mechanisms that may be of varying importance in individual patients include chronic hypercapnia and/or hypoxia, nutritional depletion, steroid usage, and oxidative stress. Potential therapies include exercise training, oxygen supplementation, nutritional repletion, and administration of anabolic hormones.</p> |
| first_indexed | 2024-12-18T05:14:27Z |
| format | Article |
| id | doaj.art-dbcee14ee3df4f56a48c1edde0042b64 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-18T05:14:27Z |
| publishDate | 2001-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-dbcee14ee3df4f56a48c1edde0042b642022-12-21T21:19:49ZengBMCRespiratory Research1465-99212001-05-012421622410.1186/rr60Skeletal muscle dysfunction in chronic obstructive pulmonary diseaseBozkanat ErkanJeffery Mador M<p>Abstract</p> <p>It has become increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Muscle strength and endurance are decreased, whereas muscle fatigability is increased. There is a reduced proportion of type I fibers and an increase in type II fibers. Muscle atrophy occurs with a reduction in fiber cross-sectional area. Oxidative enzyme activity is decreased, and measurement of muscle bioenergetics during exercise reveals a reduced aerobic capacity. Deconditioning is probably very important mechanistically. Other mechanisms that may be of varying importance in individual patients include chronic hypercapnia and/or hypoxia, nutritional depletion, steroid usage, and oxidative stress. Potential therapies include exercise training, oxygen supplementation, nutritional repletion, and administration of anabolic hormones.</p>http://dx.doi.org/10.1186/rr60exerciselung diseasesmusclenutrition disorderobstructiverehabilitationskeletal |
| spellingShingle | Bozkanat Erkan Jeffery Mador M Skeletal muscle dysfunction in chronic obstructive pulmonary disease Respiratory Research exercise lung diseases muscle nutrition disorder obstructive rehabilitation skeletal |
| title | Skeletal muscle dysfunction in chronic obstructive pulmonary disease |
| title_full | Skeletal muscle dysfunction in chronic obstructive pulmonary disease |
| title_fullStr | Skeletal muscle dysfunction in chronic obstructive pulmonary disease |
| title_full_unstemmed | Skeletal muscle dysfunction in chronic obstructive pulmonary disease |
| title_short | Skeletal muscle dysfunction in chronic obstructive pulmonary disease |
| title_sort | skeletal muscle dysfunction in chronic obstructive pulmonary disease |
| topic | exercise lung diseases muscle nutrition disorder obstructive rehabilitation skeletal |
| url | http://dx.doi.org/10.1186/rr60 |
| work_keys_str_mv | AT bozkanaterkan skeletalmuscledysfunctioninchronicobstructivepulmonarydisease AT jefferymadorm skeletalmuscledysfunctioninchronicobstructivepulmonarydisease |