Immunomodulatory Role of Neuropeptides in the Cornea
The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune systems. The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privile...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1985 |
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| author | Sudan Puri Brendan M. Kenyon Pedram Hamrah |
| author_facet | Sudan Puri Brendan M. Kenyon Pedram Hamrah |
| author_sort | Sudan Puri |
| collection | DOAJ |
| description | The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune systems. The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege, in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells. As research in this area expands, further insights are made into the role of neuropeptides and their immunomodulatory functions in the healthy and diseased cornea. Much remains to be known regarding the details of neuropeptide signaling and how it contributes to pathophysiology, which is likely due to complex interactions among neuropeptides, receptor isoform-specific signaling events, and the inflammatory microenvironment in disease. However, progress in this area has led to an increase in studies that have begun modulating neuropeptide activity for the treatment of corneal diseases with promising results, necessitating the need for a comprehensive review of the literature. This review focuses on the role of neuropeptides in maintaining the homeostasis of the ocular surface, alterations in disease settings, and the possible therapeutic potential of targeting these systems. |
| first_indexed | 2024-03-09T11:50:54Z |
| format | Article |
| id | doaj.art-dbcf67bdcdda46b1b2dad1aa9e79af63 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:50:54Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-dbcf67bdcdda46b1b2dad1aa9e79af632023-11-30T23:15:19ZengMDPI AGBiomedicines2227-90592022-08-01108198510.3390/biomedicines10081985Immunomodulatory Role of Neuropeptides in the CorneaSudan Puri0Brendan M. Kenyon1Pedram Hamrah2Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USACenter for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USACenter for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USAThe transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune systems. The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege, in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells. As research in this area expands, further insights are made into the role of neuropeptides and their immunomodulatory functions in the healthy and diseased cornea. Much remains to be known regarding the details of neuropeptide signaling and how it contributes to pathophysiology, which is likely due to complex interactions among neuropeptides, receptor isoform-specific signaling events, and the inflammatory microenvironment in disease. However, progress in this area has led to an increase in studies that have begun modulating neuropeptide activity for the treatment of corneal diseases with promising results, necessitating the need for a comprehensive review of the literature. This review focuses on the role of neuropeptides in maintaining the homeostasis of the ocular surface, alterations in disease settings, and the possible therapeutic potential of targeting these systems.https://www.mdpi.com/2227-9059/10/8/1985ocular immune privilegeneuropeptidesreceptorsneuroimmune interactionsocular surfacecornea |
| spellingShingle | Sudan Puri Brendan M. Kenyon Pedram Hamrah Immunomodulatory Role of Neuropeptides in the Cornea Biomedicines ocular immune privilege neuropeptides receptors neuroimmune interactions ocular surface cornea |
| title | Immunomodulatory Role of Neuropeptides in the Cornea |
| title_full | Immunomodulatory Role of Neuropeptides in the Cornea |
| title_fullStr | Immunomodulatory Role of Neuropeptides in the Cornea |
| title_full_unstemmed | Immunomodulatory Role of Neuropeptides in the Cornea |
| title_short | Immunomodulatory Role of Neuropeptides in the Cornea |
| title_sort | immunomodulatory role of neuropeptides in the cornea |
| topic | ocular immune privilege neuropeptides receptors neuroimmune interactions ocular surface cornea |
| url | https://www.mdpi.com/2227-9059/10/8/1985 |
| work_keys_str_mv | AT sudanpuri immunomodulatoryroleofneuropeptidesinthecornea AT brendanmkenyon immunomodulatoryroleofneuropeptidesinthecornea AT pedramhamrah immunomodulatoryroleofneuropeptidesinthecornea |