The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic Rats
Background: Diabetes mellitus is a chronic metabolic disorder with the main symptom of elevated blood sugar. Many drugs are now used to control diabetes. The aim of this study was to investigate the effect of Rosa damascena extract on blood glucose and insulin levels in diabetic rat models. Methods...
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| Format: | Article |
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Isfahan University of Medical Sciences
2020-09-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/13103 |
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| author | Ebrahim Esfandiari Shima Rouhollahi Sayed Mostafa Ghanadian Fatemeh Sadat Sadat Mostafavi |
| author_facet | Ebrahim Esfandiari Shima Rouhollahi Sayed Mostafa Ghanadian Fatemeh Sadat Sadat Mostafavi |
| author_sort | Ebrahim Esfandiari |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a chronic metabolic disorder with the main symptom of elevated blood sugar. Many drugs are now used to control diabetes. The aim of this study was to investigate the effect of Rosa damascena extract on blood glucose and insulin levels in diabetic rat models.
Methods: In this study, 100 male rats were divided into 10 equal groups of control, untreated diabetic, gavage stress, insulin treatment, and three healthy groups receiving different doses of extract (300, 600, and 900 mg/kg). Blood samples were taken at the day 0, 17, 31, and 45, and blood glucose, insulin, and malondialdehyde (MDA) levels were measured. Statistical analysis was performed using analysis of variance (ANOVA), and P < 0.050 was considered statistically significant.
Findings: There was no significant difference in mean fasting blood glucose and insulin level of different groups before beginning the interventions. Rose extract at the dose of 900 mg/kg significantly decreased blood glucose level (P = 0.007) and significantly increased blood insulin level (P = 0.009) in diabetic rats compared to diabetic control group. This dose of extract also reduced blood glucose and increased insulin levels in healthy non-diabetic rats.
Conclusion: Using rose extract can decrease blood sugar, and increase insulin levels. It seems that this extract could be of interest to researchers as a suitable therapeutic potential. |
| first_indexed | 2024-03-12T08:46:16Z |
| format | Article |
| id | doaj.art-dbd009cd51f54a4ba165f49e3e96a0ff |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:46:16Z |
| publishDate | 2020-09-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-dbd009cd51f54a4ba165f49e3e96a0ff2023-09-02T16:26:14ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2020-09-013858452152710.22122/jims.v38i584.131033688The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic RatsEbrahim Esfandiari0Shima Rouhollahi1Sayed Mostafa Ghanadian2Fatemeh Sadat Sadat Mostafavi3Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMSc Student, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences AND Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Diabetes mellitus is a chronic metabolic disorder with the main symptom of elevated blood sugar. Many drugs are now used to control diabetes. The aim of this study was to investigate the effect of Rosa damascena extract on blood glucose and insulin levels in diabetic rat models. Methods: In this study, 100 male rats were divided into 10 equal groups of control, untreated diabetic, gavage stress, insulin treatment, and three healthy groups receiving different doses of extract (300, 600, and 900 mg/kg). Blood samples were taken at the day 0, 17, 31, and 45, and blood glucose, insulin, and malondialdehyde (MDA) levels were measured. Statistical analysis was performed using analysis of variance (ANOVA), and P < 0.050 was considered statistically significant. Findings: There was no significant difference in mean fasting blood glucose and insulin level of different groups before beginning the interventions. Rose extract at the dose of 900 mg/kg significantly decreased blood glucose level (P = 0.007) and significantly increased blood insulin level (P = 0.009) in diabetic rats compared to diabetic control group. This dose of extract also reduced blood glucose and increased insulin levels in healthy non-diabetic rats. Conclusion: Using rose extract can decrease blood sugar, and increase insulin levels. It seems that this extract could be of interest to researchers as a suitable therapeutic potential.http://jims.mui.ac.ir/index.php/jims/article/view/13103diabetes mellitusrosa, insulinblood glucose |
| spellingShingle | Ebrahim Esfandiari Shima Rouhollahi Sayed Mostafa Ghanadian Fatemeh Sadat Sadat Mostafavi The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic Rats مجله دانشکده پزشکی اصفهان diabetes mellitus rosa, insulin blood glucose |
| title | The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic Rats |
| title_full | The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic Rats |
| title_fullStr | The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic Rats |
| title_full_unstemmed | The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic Rats |
| title_short | The Effect of Rosa Damascena Extract on Blood Glucose and Insulin levels in Diabetic Rats |
| title_sort | effect of rosa damascena extract on blood glucose and insulin levels in diabetic rats |
| topic | diabetes mellitus rosa, insulin blood glucose |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/13103 |
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