Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms.
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability. Paradoxically, transcription of heterochromatic sequences is required for establishment of heterochromatin in diverse eukaryotic s...
| Հիմնական հեղինակներ: | , , , , , , |
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| Ձևաչափ: | Հոդված |
| Լեզու: | English |
| Հրապարակվել է: |
Public Library of Science (PLoS)
2023-11-01
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| Շարք: | PLoS Genetics |
| Առցանց հասանելիություն: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010492&type=printable |