Dandy–Walker malformation and intermittent explosive disorder: A case report

Dandy–Walker malformation is a group of brain malformations that sometimes present with psychotic features, violent and impulsive behavior, or mood symptoms. Here, we present a case report of a patient with Dandy–Walker malformation who presented with intermittent explosive disorder. A young man, ag...

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Main Authors: Mohamed El Tahir, Mai Ahmed, Salma Salman, Bushra Elhusein
Format: Article
Language:English
Published: SAGE Publishing 2022-06-01
Series:SAGE Open Medical Case Reports
Online Access:https://doi.org/10.1177/2050313X221103355
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author Mohamed El Tahir
Mai Ahmed
Salma Salman
Bushra Elhusein
author_facet Mohamed El Tahir
Mai Ahmed
Salma Salman
Bushra Elhusein
author_sort Mohamed El Tahir
collection DOAJ
description Dandy–Walker malformation is a group of brain malformations that sometimes present with psychotic features, violent and impulsive behavior, or mood symptoms. Here, we present a case report of a patient with Dandy–Walker malformation who presented with intermittent explosive disorder. A young man, aged 18 years, was brought to the author’s hospital [Hamad Medical Corporation] with anger outbursts, irritable mood, and violent behavior. His magnetic resonance imaging scans showed typical alterations of Dandy–Walker malformation. He also had mild intellectual disabilities and epilepsy. After a few weeks of treatment with sodium valproate 1000 mg/day and risperidone 2 mg/day, his condition improved, and his violent behavior was significantly reduced in 3 months, 6 months, and 1 year of follow-up. There is broad consensus that Dandy–Walker malformation is associated with psychosis and other behavioral abnormalities because of a possible disruption in the prefrontal, thalamic, and cerebellar circuits. The link between Dandy–Walker malformation and intermittent explosive disorder may help us understand this type of brain malformation as a potential psychiatric comorbidity.
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spelling doaj.art-dbd21377cd7d4ba8aafab0a4439dc0142022-12-22T00:38:22ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2022-06-011010.1177/2050313X221103355Dandy–Walker malformation and intermittent explosive disorder: A case reportMohamed El Tahir0Mai Ahmed1Salma Salman2Bushra Elhusein3Department of Psychiatry, Hamad Medical Corporation, Doha, QatarNorthern Ontario School of Medicine, Sault Ste. Marie, ON, CanadaHamad Medical Corporation, Doha, QatarAmbulatory Program—Urgent Consultation Service and Consultation Liaison Psychiatry, London Health Sciences Centre (LHSC), Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CanadaDandy–Walker malformation is a group of brain malformations that sometimes present with psychotic features, violent and impulsive behavior, or mood symptoms. Here, we present a case report of a patient with Dandy–Walker malformation who presented with intermittent explosive disorder. A young man, aged 18 years, was brought to the author’s hospital [Hamad Medical Corporation] with anger outbursts, irritable mood, and violent behavior. His magnetic resonance imaging scans showed typical alterations of Dandy–Walker malformation. He also had mild intellectual disabilities and epilepsy. After a few weeks of treatment with sodium valproate 1000 mg/day and risperidone 2 mg/day, his condition improved, and his violent behavior was significantly reduced in 3 months, 6 months, and 1 year of follow-up. There is broad consensus that Dandy–Walker malformation is associated with psychosis and other behavioral abnormalities because of a possible disruption in the prefrontal, thalamic, and cerebellar circuits. The link between Dandy–Walker malformation and intermittent explosive disorder may help us understand this type of brain malformation as a potential psychiatric comorbidity.https://doi.org/10.1177/2050313X221103355
spellingShingle Mohamed El Tahir
Mai Ahmed
Salma Salman
Bushra Elhusein
Dandy–Walker malformation and intermittent explosive disorder: A case report
SAGE Open Medical Case Reports
title Dandy–Walker malformation and intermittent explosive disorder: A case report
title_full Dandy–Walker malformation and intermittent explosive disorder: A case report
title_fullStr Dandy–Walker malformation and intermittent explosive disorder: A case report
title_full_unstemmed Dandy–Walker malformation and intermittent explosive disorder: A case report
title_short Dandy–Walker malformation and intermittent explosive disorder: A case report
title_sort dandy walker malformation and intermittent explosive disorder a case report
url https://doi.org/10.1177/2050313X221103355
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