MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASON
Aim. Study the circulation of respiratory viruses in children with community-acquired pneumonia (CAP) during the period from October 2012 to May 2013. Materials and methods. 136 children with CAP aged from 3 months to 16 years with ARI symptoms at the disease debut were studied. RNA/DNA of influenza...
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2015-04-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
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| Online Access: | https://microbiol.crie.ru/jour/article/view/14046 |
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| author | O. V Ostrovskaya G. N Kholodok N. M Ivakhnishina N. V Morozova T. N Karavyanskaya E. M Golubeva V. I Reznik L. V Savosina L. A Lebedeva E. N Prisyazhnyuk V. K Kozlov |
| author_facet | O. V Ostrovskaya G. N Kholodok N. M Ivakhnishina N. V Morozova T. N Karavyanskaya E. M Golubeva V. I Reznik L. V Savosina L. A Lebedeva E. N Prisyazhnyuk V. K Kozlov |
| author_sort | O. V Ostrovskaya |
| collection | DOAJ |
| description | Aim. Study the circulation of respiratory viruses in children with community-acquired pneumonia (CAP) during the period from October 2012 to May 2013. Materials and methods. 136 children with CAP aged from 3 months to 16 years with ARI symptoms at the disease debut were studied. RNA/DNA of influenza A, B, parainfluenza (PI), adeno-, rhino-, RS-viruses, corona-, metapneumo- (MPV) and bocaviruses were detected in nasopharynx smears by PCR with hybridization-fluorescent detection in real time. Antibodies against influenza viruses A/H1N1/pdm09 California/07/09, epidemic reference strains of influenza viruses A/H1N1/Brisbane/59/07, A/ H3N2/Victoria/361/2011, B/Wisconsin/1/10, against PI viruses type 1, 2, 3 were determined in paired sera by HAI. Results. In February-March 2013 the number of children protected by antibodies against influenza decreased, and circulation of influenza viruses A/H3N2 and A/H1N1/ pdm09 was detected. Rhinoviruses and PI viruses were determined throughout the epidemic season, bocavirus and adenoviruses - during the autumn-winter period, RS-virus and MPV - during winter-spring. Coronaviruses were not detected. The peak of virus detection was established in February, when the threshold of influenza and ARI morbidity was exceeded. The main pathogens of children of the first 3 years of life are rhinoviruses, RS-virus, PI viruses and bocavirus. RS-virus infection at the debut of CAP in children younger than 3 years in 55.5% of cases is associated with the development of broncho-obstructive syndrome. Bocavirus infection in 50% of cases progresses with laryngo-tracheitis and bronchiolitis. Conclusion. The fraction of viruses in etiologic structure ofARI in children varies depending on immune layer, season and age ofchildren. Etiology of viral infection at the debut of CAP could only be proven using specialized laboratory studies. |
| first_indexed | 2024-03-13T00:08:10Z |
| format | Article |
| id | doaj.art-dbd29cc0c6d34a72a706db6eebed29cc |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-03-13T00:08:10Z |
| publishDate | 2015-04-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-dbd29cc0c6d34a72a706db6eebed29cc2023-07-12T20:20:43ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132015-04-0192259652471MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASONO. V Ostrovskaya0G. N Kholodok1N. M Ivakhnishina2N. V Morozova3T. N Karavyanskaya4E. M Golubeva5V. I Reznik6L. V Savosina7L. A Lebedeva8E. N Prisyazhnyuk9V. K Kozlov10Research Institute of Maternity and Childhood ProtectionResearch Institute of Maternity and Childhood ProtectionResearch Institute of Maternity and Childhood ProtectionFar-Eastern State Medical UniversityAdministration of Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Khabarovsk RegionAdministration of Federal Service of Surveillance for Protection of Consumers Rights and Human Welfare for Khabarovsk RegionCentre of Hygiene and Epidemiology in Khabarovsk RegionCentre of Hygiene and Epidemiology in Khabarovsk RegionCentre of Hygiene and Epidemiology in Khabarovsk RegionCentre of Hygiene and Epidemiology in Khabarovsk RegionResearch Institute of Maternity and Childhood Protection, Far-Eastern State Medical UniversityAim. Study the circulation of respiratory viruses in children with community-acquired pneumonia (CAP) during the period from October 2012 to May 2013. Materials and methods. 136 children with CAP aged from 3 months to 16 years with ARI symptoms at the disease debut were studied. RNA/DNA of influenza A, B, parainfluenza (PI), adeno-, rhino-, RS-viruses, corona-, metapneumo- (MPV) and bocaviruses were detected in nasopharynx smears by PCR with hybridization-fluorescent detection in real time. Antibodies against influenza viruses A/H1N1/pdm09 California/07/09, epidemic reference strains of influenza viruses A/H1N1/Brisbane/59/07, A/ H3N2/Victoria/361/2011, B/Wisconsin/1/10, against PI viruses type 1, 2, 3 were determined in paired sera by HAI. Results. In February-March 2013 the number of children protected by antibodies against influenza decreased, and circulation of influenza viruses A/H3N2 and A/H1N1/ pdm09 was detected. Rhinoviruses and PI viruses were determined throughout the epidemic season, bocavirus and adenoviruses - during the autumn-winter period, RS-virus and MPV - during winter-spring. Coronaviruses were not detected. The peak of virus detection was established in February, when the threshold of influenza and ARI morbidity was exceeded. The main pathogens of children of the first 3 years of life are rhinoviruses, RS-virus, PI viruses and bocavirus. RS-virus infection at the debut of CAP in children younger than 3 years in 55.5% of cases is associated with the development of broncho-obstructive syndrome. Bocavirus infection in 50% of cases progresses with laryngo-tracheitis and bronchiolitis. Conclusion. The fraction of viruses in etiologic structure ofARI in children varies depending on immune layer, season and age ofchildren. Etiology of viral infection at the debut of CAP could only be proven using specialized laboratory studies.https://microbiol.crie.ru/jour/article/view/14046respiratory viruseschildrencommunity-acquired pneumoniapcr |
| spellingShingle | O. V Ostrovskaya G. N Kholodok N. M Ivakhnishina N. V Morozova T. N Karavyanskaya E. M Golubeva V. I Reznik L. V Savosina L. A Lebedeva E. N Prisyazhnyuk V. K Kozlov MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASON Журнал микробиологии, эпидемиологии и иммунобиологии respiratory viruses children community-acquired pneumonia pcr |
| title | MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASON |
| title_full | MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASON |
| title_fullStr | MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASON |
| title_full_unstemmed | MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASON |
| title_short | MONITORING OF INFLUENZA AND OTHER RESPIRATORY DISEASES CAUSATIVE AGENTS IN CHILDREN, HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN 2012 - 2013 EPIDEMIC SEASON |
| title_sort | monitoring of influenza and other respiratory diseases causative agents in children hospitalized with community acquired pneumonia in 2012 2013 epidemic season |
| topic | respiratory viruses children community-acquired pneumonia pcr |
| url | https://microbiol.crie.ru/jour/article/view/14046 |
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