Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation
Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and transferrin receptors, to nascent autophagosomes.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31465-3 |
| _version_ | 1811328294996410368 |
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| author | Paula P. Coelho Geoffrey G. Hesketh Annika Pedersen Elena Kuzmin Anne-Marie N. Fortier Emily S. Bell Colin D. H. Ratcliffe Anne-Claude Gingras Morag Park |
| author_facet | Paula P. Coelho Geoffrey G. Hesketh Annika Pedersen Elena Kuzmin Anne-Marie N. Fortier Emily S. Bell Colin D. H. Ratcliffe Anne-Claude Gingras Morag Park |
| author_sort | Paula P. Coelho |
| collection | DOAJ |
| description | Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and transferrin receptors, to nascent autophagosomes. |
| first_indexed | 2024-04-13T15:23:47Z |
| format | Article |
| id | doaj.art-dbd2c247c92d430b8021941e40af2dd4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T15:23:47Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dbd2c247c92d430b8021941e40af2dd42022-12-22T02:41:35ZengNature PortfolioNature Communications2041-17232022-07-0113111610.1038/s41467-022-31465-3Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradationPaula P. Coelho0Geoffrey G. Hesketh1Annika Pedersen2Elena Kuzmin3Anne-Marie N. Fortier4Emily S. Bell5Colin D. H. Ratcliffe6Anne-Claude Gingras7Morag Park8Rosalind and Morris Goodman Cancer Institute, McGill UniversityLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 992A-600 University AvenueRosalind and Morris Goodman Cancer Institute, McGill UniversityRosalind and Morris Goodman Cancer Institute, McGill UniversityRosalind and Morris Goodman Cancer Institute, McGill UniversityDepartment of Biochemistry and Molecular Biology, Pennsylvania State UniversityRosalind and Morris Goodman Cancer Institute, McGill UniversityLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 992A-600 University AvenueRosalind and Morris Goodman Cancer Institute, McGill UniversityAutophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and transferrin receptors, to nascent autophagosomes.https://doi.org/10.1038/s41467-022-31465-3 |
| spellingShingle | Paula P. Coelho Geoffrey G. Hesketh Annika Pedersen Elena Kuzmin Anne-Marie N. Fortier Emily S. Bell Colin D. H. Ratcliffe Anne-Claude Gingras Morag Park Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation Nature Communications |
| title | Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation |
| title_full | Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation |
| title_fullStr | Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation |
| title_full_unstemmed | Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation |
| title_short | Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation |
| title_sort | endosomal lc3c pathway selectively targets plasma membrane cargo for autophagic degradation |
| url | https://doi.org/10.1038/s41467-022-31465-3 |
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