Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation
Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and transferrin receptors, to nascent autophagosomes.
Main Authors: | Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-31465-3 |
Similar Items
-
FERARI and cargo adaptors coordinate cargo flow through sorting endosomes
by: Jachen A. Solinger, et al.
Published: (2022-08-01) -
The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9
by: Brian T Emmer, et al.
Published: (2018-09-01) -
Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes
by: Yohei Ohashi, et al.
Published: (2020-06-01) -
Imaging and Quantitation Techniques for Tracking Cargo along Endosome-to-Golgi Transport Pathways
by: Paul A. Gleeson, et al.
Published: (2013-02-01) -
The role of autophagic degradation in Cancer Treatment
by: Xiao-Feng Zhu
Published: (2017-03-01)