Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samplesResearch in context

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samplesResearch in context

Background: Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune signals that would precede the onset of rejection, p...

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Main Authors: Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Tjir-Li Tsui, Claire Duff, Clara Domingo-Vila, Yogesh Kamra, Florence Delaney, Rosa Montero, Anastasia Spiridou, Theodoros Kassimatis, Sui Phin-Kon, Beatriz Tucker, Christopher Farmer, Terry B. Strom, Graham M. Lord, Irene Rebollo-Mesa, Daniel Stahl, Steven Sacks, Maria P. Hernandez-Fuentes, Paramit Chowdhury
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419300660

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