Effects of CYP3A4*22 and POR*28 variations on the pharmacokinetics of tacrolimus in renal transplant recipients: a meta-analysis of 18 observational studies

Effects of CYP3A4*22 and POR*28 variations on the pharmacokinetics of tacrolimus in renal transplant recipients: a meta-analysis of 18 observational studies

Abstract Purpose This study aimed to investigate the association between cytochrome P450 (CYP) 3A4*22 and cytochrome P450 oxidoreductase (POR)*28 variations and the pharmacokinetics of tacrolimus. Methods Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science (SCI), MEDLINE, and Em...

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Bibliographic Details
Main Authors: Ze Li, Xiaozhen Wang, Dandan Li, Sheng Cheng, Zhe Li, Heng Guo, Yiwen Dong, Yingming Zheng, Xingang Li
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Nephrology
Subjects:
Meta-analysis
Genetic polymorphisms
Tacrolimus
Pharmacokinetics
Renal transplant recipients
Online Access:https://doi.org/10.1186/s12882-024-03467-4

Internet

https://doi.org/10.1186/s12882-024-03467-4

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