The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential
A growing body of evidence has demonstrated a relationship between the microbiome, adiposity, and cancer development. The microbiome is emerging as an important factor in metabolic disease and cancer pathogenesis. This review aimed to highlight the role of the microbiome in obesity and its associati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/12/1402 |
| _version_ | 1797379745288028160 |
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| author | Dimiter Avtanski Varun Reddy Radoslav Stojchevski Nikola Hadzi-Petrushev Mitko Mladenov |
| author_facet | Dimiter Avtanski Varun Reddy Radoslav Stojchevski Nikola Hadzi-Petrushev Mitko Mladenov |
| author_sort | Dimiter Avtanski |
| collection | DOAJ |
| description | A growing body of evidence has demonstrated a relationship between the microbiome, adiposity, and cancer development. The microbiome is emerging as an important factor in metabolic disease and cancer pathogenesis. This review aimed to highlight the role of the microbiome in obesity and its association with cancer, with a particular focus on breast cancer. This review discusses how microbiota dysbiosis may contribute to obesity and obesity-related diseases, which are linked to breast cancer. It also explores the potential of the gut microbiome to influence systemic immunity, leading to carcinogenesis via the modulation of immune function. This review underscores the potential use of the microbiome profile as a diagnostic tool and treatment target, with strategies including probiotics, fecal microbiota transplantation, and dietary interventions. However, this emphasizes the need for more research to fully understand the complex relationship between the microbiome, metabolic disorders, and breast cancer. Future studies should focus on elucidating the mechanisms underlying the impact of the microbiome on breast cancer and exploring the potential of the microbiota profile as a biomarker and treatment target. |
| first_indexed | 2024-03-08T20:28:26Z |
| format | Article |
| id | doaj.art-dbd60118c28c44329f6a0c2cdda1a8b9 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-08T20:28:26Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-dbd60118c28c44329f6a0c2cdda1a8b92023-12-22T14:30:50ZengMDPI AGPathogens2076-08172023-11-011212140210.3390/pathogens12121402The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic PotentialDimiter Avtanski0Varun Reddy1Radoslav Stojchevski2Nikola Hadzi-Petrushev3Mitko Mladenov4Friedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, New York, NY 10022, USANew York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11545, USAFriedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, New York, NY 10022, USAFaculty of Natural Sciences and Mathematics, Institute of Biology, Ss. Cyril and Methodius University, 1000 Skopje, North MacedoniaFaculty of Natural Sciences and Mathematics, Institute of Biology, Ss. Cyril and Methodius University, 1000 Skopje, North MacedoniaA growing body of evidence has demonstrated a relationship between the microbiome, adiposity, and cancer development. The microbiome is emerging as an important factor in metabolic disease and cancer pathogenesis. This review aimed to highlight the role of the microbiome in obesity and its association with cancer, with a particular focus on breast cancer. This review discusses how microbiota dysbiosis may contribute to obesity and obesity-related diseases, which are linked to breast cancer. It also explores the potential of the gut microbiome to influence systemic immunity, leading to carcinogenesis via the modulation of immune function. This review underscores the potential use of the microbiome profile as a diagnostic tool and treatment target, with strategies including probiotics, fecal microbiota transplantation, and dietary interventions. However, this emphasizes the need for more research to fully understand the complex relationship between the microbiome, metabolic disorders, and breast cancer. Future studies should focus on elucidating the mechanisms underlying the impact of the microbiome on breast cancer and exploring the potential of the microbiota profile as a biomarker and treatment target.https://www.mdpi.com/2076-0817/12/12/1402microbiomeobesitybreast cancerdysbiosisdiagnostictherapeutic |
| spellingShingle | Dimiter Avtanski Varun Reddy Radoslav Stojchevski Nikola Hadzi-Petrushev Mitko Mladenov The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential Pathogens microbiome obesity breast cancer dysbiosis diagnostic therapeutic |
| title | The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential |
| title_full | The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential |
| title_fullStr | The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential |
| title_full_unstemmed | The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential |
| title_short | The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential |
| title_sort | microbiome in the obesity breast cancer axis diagnostic and therapeutic potential |
| topic | microbiome obesity breast cancer dysbiosis diagnostic therapeutic |
| url | https://www.mdpi.com/2076-0817/12/12/1402 |
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