Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials.
The relation of LCT-13910 genotypes and bone mineral density (BMD) has been the subject of modern-day human population studies, giving inconsistent results. In the present study we analyze for the first time a relation of LCT-13910 genotypes and BMD in historical skeletal individuals. Ancient popula...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5927400?pdf=render |
| _version_ | 1811259123570835456 |
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| author | Barbara Mnich Anna Elżbieta Spinek Maciej Chyleński Aleksandra Sommerfeld Miroslawa Dabert Anna Juras Krzysztof Szostek |
| author_facet | Barbara Mnich Anna Elżbieta Spinek Maciej Chyleński Aleksandra Sommerfeld Miroslawa Dabert Anna Juras Krzysztof Szostek |
| author_sort | Barbara Mnich |
| collection | DOAJ |
| description | The relation of LCT-13910 genotypes and bone mineral density (BMD) has been the subject of modern-day human population studies, giving inconsistent results. In the present study we analyze for the first time a relation of LCT-13910 genotypes and BMD in historical skeletal individuals. Ancient population might be a model for testing this association due to elimination of non-natural factors affecting bone density. Among 22 medieval individuals from Sanok churchyard (South-Eastern Poland; dated from XIV to XVII c. AD) we identified 4 individuals with osteoporosis (mean BMD = 0.468 g/cm2, SD = 0.090), 10 individuals with osteopenia (mean BMD = 0.531 g/cm2, SD = 0.066) and 8 individuals with normal BMD values (mean BMD = 0,642 g/cm2, SD = 0.060). Analyses of BMD and LCT-13910 genotypes revealed that mean BMD was the highest (0.583 g/cm2, SD = 0.065) in the individuals with lactose tolerance genotypes (TT and CT). We also found possible association of lower BMD at the radius and CC genotypes due to higher but not statistically significant frequency of osteoporosis in the lactose intolerant group (p = 0.60). Statistically significant correlation was found between BMD and females aged 20-35 years, with tendency to reduce BMD with age (p = 0.02). |
| first_indexed | 2024-04-12T18:25:43Z |
| format | Article |
| id | doaj.art-dbd65086bd914e12b9d42edfca3fe0f2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T18:25:43Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dbd65086bd914e12b9d42edfca3fe0f22022-12-22T03:21:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019496610.1371/journal.pone.0194966Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials.Barbara MnichAnna Elżbieta SpinekMaciej ChyleńskiAleksandra SommerfeldMiroslawa DabertAnna JurasKrzysztof SzostekThe relation of LCT-13910 genotypes and bone mineral density (BMD) has been the subject of modern-day human population studies, giving inconsistent results. In the present study we analyze for the first time a relation of LCT-13910 genotypes and BMD in historical skeletal individuals. Ancient population might be a model for testing this association due to elimination of non-natural factors affecting bone density. Among 22 medieval individuals from Sanok churchyard (South-Eastern Poland; dated from XIV to XVII c. AD) we identified 4 individuals with osteoporosis (mean BMD = 0.468 g/cm2, SD = 0.090), 10 individuals with osteopenia (mean BMD = 0.531 g/cm2, SD = 0.066) and 8 individuals with normal BMD values (mean BMD = 0,642 g/cm2, SD = 0.060). Analyses of BMD and LCT-13910 genotypes revealed that mean BMD was the highest (0.583 g/cm2, SD = 0.065) in the individuals with lactose tolerance genotypes (TT and CT). We also found possible association of lower BMD at the radius and CC genotypes due to higher but not statistically significant frequency of osteoporosis in the lactose intolerant group (p = 0.60). Statistically significant correlation was found between BMD and females aged 20-35 years, with tendency to reduce BMD with age (p = 0.02).http://europepmc.org/articles/PMC5927400?pdf=render |
| spellingShingle | Barbara Mnich Anna Elżbieta Spinek Maciej Chyleński Aleksandra Sommerfeld Miroslawa Dabert Anna Juras Krzysztof Szostek Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials. PLoS ONE |
| title | Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials. |
| title_full | Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials. |
| title_fullStr | Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials. |
| title_full_unstemmed | Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials. |
| title_short | Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials. |
| title_sort | analysis of lct 13910 genotypes and bone mineral density in ancient skeletal materials |
| url | http://europepmc.org/articles/PMC5927400?pdf=render |
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