Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients?
Abstract Background Coronavirus Disease-2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Coronavirus-2, still remains prevalent and severe. We aimed to evaluate the effects of pre-existing atrial fibrillation and new-onset atrial fibrillation (NOAF) on the clinical severity and mortality...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43044-022-00291-9 |
| _version_ | 1828186825871589376 |
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| author | Selim Aydemir Emrah Aksakal Faruk Aydınyılmaz Oktay Gülcü İbrahim Saraç Sidar Şiyar Aydın Remziye Doğan Merve Lazoğlu Kamuran Kalkan |
| author_facet | Selim Aydemir Emrah Aksakal Faruk Aydınyılmaz Oktay Gülcü İbrahim Saraç Sidar Şiyar Aydın Remziye Doğan Merve Lazoğlu Kamuran Kalkan |
| author_sort | Selim Aydemir |
| collection | DOAJ |
| description | Abstract Background Coronavirus Disease-2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Coronavirus-2, still remains prevalent and severe. We aimed to evaluate the effects of pre-existing atrial fibrillation and new-onset atrial fibrillation (NOAF) on the clinical severity and mortality of COVID-19. Results Between April and December 2020, 5577 patients with positive PCR and/or COVID-19 compatible findings in computed tomography hospitalized were enrolled retrospectively. Total and in-hospital mortality, need for intensive care unit (ICU), need for mechanical ventilation, and recurrent hospitalization results of 286 patients with pre-existing AF before hospitalization and 82 patients with NOAF during hospitalization were evaluated. Preexisting AF was associated with a 2-fold increase in total and in-hospital mortality [OR (2.16 (1.62–2.89), 2.02 (1.48–2.76), P < 0.001, respectively]. NOAF was associated with a 14-fold increase in total mortality and a 12-fold increase in in-hospital mortality [OR(14.72 (9.22–23.5), 12.56 (8.02–19.68), P < 0.001], respectively]. However, pre-existing AF and NOAF resulted in increased ICU admission, mechanical ventilation, and recurrent hospitalization. In the Cox regression analysis, NOAF was observed as an independent risk factor for mortality. Conclusions Pre-existing AF and in-hospital NOAF were associated with increased mortality and severity in hospitalized COVID-19 patients. In addition, NOAF was observed as an independent prognostic indicator in terms of total mortality. |
| first_indexed | 2024-04-12T07:24:17Z |
| format | Article |
| id | doaj.art-dbd6a84962984e6db6e3ca03383bde66 |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-04-12T07:24:17Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-dbd6a84962984e6db6e3ca03383bde662022-12-22T03:42:14ZengSpringerOpenThe Egyptian Heart Journal2090-911X2022-07-017411810.1186/s43044-022-00291-9Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients?Selim Aydemir0Emrah Aksakal1Faruk Aydınyılmaz2Oktay Gülcü3İbrahim Saraç4Sidar Şiyar Aydın5Remziye Doğan6Merve Lazoğlu7Kamuran Kalkan8Department of Cardiology, Mareşal Çakmak State HospitalDepartment of Cardiology, Erzurum Education and Research Hospital, University of Health SciencesDepartment of Cardiology, Erzurum Education and Research Hospital, University of Health SciencesDepartment of Cardiology, Erzurum Education and Research Hospital, University of Health SciencesDepartment of Cardiology, Erzurum Education and Research Hospital, University of Health SciencesDepartment of Cardiology, Erzurum Education and Research Hospital, University of Health SciencesDepartment of Cardiology, Düzce Atatürk State HospitalDepartment of Midwifery, Atatürk University Faculty of Health SciencesDepartment of Cardiology, Dışkapı Yıldırım Beyazıd Education and Research Hospital, University of Health SciencesAbstract Background Coronavirus Disease-2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Coronavirus-2, still remains prevalent and severe. We aimed to evaluate the effects of pre-existing atrial fibrillation and new-onset atrial fibrillation (NOAF) on the clinical severity and mortality of COVID-19. Results Between April and December 2020, 5577 patients with positive PCR and/or COVID-19 compatible findings in computed tomography hospitalized were enrolled retrospectively. Total and in-hospital mortality, need for intensive care unit (ICU), need for mechanical ventilation, and recurrent hospitalization results of 286 patients with pre-existing AF before hospitalization and 82 patients with NOAF during hospitalization were evaluated. Preexisting AF was associated with a 2-fold increase in total and in-hospital mortality [OR (2.16 (1.62–2.89), 2.02 (1.48–2.76), P < 0.001, respectively]. NOAF was associated with a 14-fold increase in total mortality and a 12-fold increase in in-hospital mortality [OR(14.72 (9.22–23.5), 12.56 (8.02–19.68), P < 0.001], respectively]. However, pre-existing AF and NOAF resulted in increased ICU admission, mechanical ventilation, and recurrent hospitalization. In the Cox regression analysis, NOAF was observed as an independent risk factor for mortality. Conclusions Pre-existing AF and in-hospital NOAF were associated with increased mortality and severity in hospitalized COVID-19 patients. In addition, NOAF was observed as an independent prognostic indicator in terms of total mortality.https://doi.org/10.1186/s43044-022-00291-9COVID-19Atrial fibrillationMortality |
| spellingShingle | Selim Aydemir Emrah Aksakal Faruk Aydınyılmaz Oktay Gülcü İbrahim Saraç Sidar Şiyar Aydın Remziye Doğan Merve Lazoğlu Kamuran Kalkan Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients? The Egyptian Heart Journal COVID-19 Atrial fibrillation Mortality |
| title | Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients? |
| title_full | Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients? |
| title_fullStr | Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients? |
| title_full_unstemmed | Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients? |
| title_short | Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients? |
| title_sort | does new onset and pre existing atrial fibrillation predict mortality in covid 19 patients |
| topic | COVID-19 Atrial fibrillation Mortality |
| url | https://doi.org/10.1186/s43044-022-00291-9 |
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