Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albus

Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albus

Highlights DNA methylation modification plays a more crucial role than chromatin accessibility in gonad development. DNA methylation in the transcription start site plays a key role in gonad development. DNA methylation of the plastin-2 promoter inhibited gene expression. Plastin-2 is positively reg...

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Bibliographic Details
Main Authors: Qiaomu Hu, Zitong Lian, Xueping Xia, Haifeng Tian, Zhong Li
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Biology of Sex Differences
Subjects:
Sex reversal
Monopterus albus
DNA methylation
Chromatin accessibility
Epigenetic modification
Online Access:https://doi.org/10.1186/s13293-022-00484-6

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