Taxane-Induced Upper Gastrointestinal Bleeding
Docetaxel is a taxane, which is a class of chemotherapy agent used in the treatment of multiple malignancies. It is known to have gastrointestinal side effects which can range from mild symptoms such as nausea and diarrhea to more severe complications such as neutropenic enterocolitis. In the curren...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2021-09-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/517818 |
| _version_ | 1818888506453262336 |
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| author | Yao Liu Brent Hiramoto Janet Kwok Ahmad Ibrahim Sergei Tatishchev Irene Kang Rushabh Modi |
| author_facet | Yao Liu Brent Hiramoto Janet Kwok Ahmad Ibrahim Sergei Tatishchev Irene Kang Rushabh Modi |
| author_sort | Yao Liu |
| collection | DOAJ |
| description | Docetaxel is a taxane, which is a class of chemotherapy agent used in the treatment of multiple malignancies. It is known to have gastrointestinal side effects which can range from mild symptoms such as nausea and diarrhea to more severe complications such as neutropenic enterocolitis. In the current literature, taxanes have not been described to cause upper gastrointestinal bleeding and melena. Here, we present a case of a 54-year-old woman with breast cancer who developed dizziness, fatigue, and melena after receiving chemotherapy. Esophagogastroduodenoscopy revealed diffuse gastric erosions as well as ulceration and linear superficial lesions in the duodenum; biopsies from these sites showed taxane-induced toxicity. Her bleeding resolved with medical therapy and subsequent removal of docetaxel from her chemotherapy regimen. This case identifies upper gastrointestinal bleeding as a previously undescribed side effect of docetaxel therapy. Recent docetaxel use should be included in the differential diagnosis for upper gastrointestinal bleed, and diagnosis should lead to consideration of cessation of docetaxel or substitution with another chemotherapeutic agent. |
| first_indexed | 2024-12-19T16:54:12Z |
| format | Article |
| id | doaj.art-dbd72b614500462985080f752c56c23b |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-19T16:54:12Z |
| publishDate | 2021-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-dbd72b614500462985080f752c56c23b2022-12-21T20:13:27ZengKarger PublishersCase Reports in Oncology1662-65752021-09-011431373137910.1159/000517818517818Taxane-Induced Upper Gastrointestinal BleedingYao Liu0https://orcid.org/0000-0002-7151-870XBrent Hiramoto1Janet Kwok2Ahmad Ibrahim3Sergei Tatishchev4Irene Kang5Rushabh Modi6Department of Internal Medicine, University of Southern California ‒ Internal Medicine Residency, Los Angeles, CA, USADepartment of Internal Medicine, University of Southern California ‒ Internal Medicine Residency, Los Angeles, CA, USADivision of Gastrointestinal and Liver Disease, Department of Internal Medicine, University of Southern California ‒ Keck School of Medicine, Los Angeles, CA, USADepartment of Pathology, University of Southern California ‒ Keck School of Medicine, Los Angeles, CA, USADepartment of Pathology, University of Southern California ‒ Keck School of Medicine, Los Angeles, CA, USADivision of Oncology, Department of Internal Medicine, University of Southern California ‒ Keck School of Medicine, Los Angeles, CA, USADivision of Gastrointestinal and Liver Disease, Department of Internal Medicine, University of Southern California ‒ Keck School of Medicine, Los Angeles, CA, USADocetaxel is a taxane, which is a class of chemotherapy agent used in the treatment of multiple malignancies. It is known to have gastrointestinal side effects which can range from mild symptoms such as nausea and diarrhea to more severe complications such as neutropenic enterocolitis. In the current literature, taxanes have not been described to cause upper gastrointestinal bleeding and melena. Here, we present a case of a 54-year-old woman with breast cancer who developed dizziness, fatigue, and melena after receiving chemotherapy. Esophagogastroduodenoscopy revealed diffuse gastric erosions as well as ulceration and linear superficial lesions in the duodenum; biopsies from these sites showed taxane-induced toxicity. Her bleeding resolved with medical therapy and subsequent removal of docetaxel from her chemotherapy regimen. This case identifies upper gastrointestinal bleeding as a previously undescribed side effect of docetaxel therapy. Recent docetaxel use should be included in the differential diagnosis for upper gastrointestinal bleed, and diagnosis should lead to consideration of cessation of docetaxel or substitution with another chemotherapeutic agent.https://www.karger.com/Article/FullText/517818gastrointestinal bleedchemotherapybreast cancertaxane |
| spellingShingle | Yao Liu Brent Hiramoto Janet Kwok Ahmad Ibrahim Sergei Tatishchev Irene Kang Rushabh Modi Taxane-Induced Upper Gastrointestinal Bleeding Case Reports in Oncology gastrointestinal bleed chemotherapy breast cancer taxane |
| title | Taxane-Induced Upper Gastrointestinal Bleeding |
| title_full | Taxane-Induced Upper Gastrointestinal Bleeding |
| title_fullStr | Taxane-Induced Upper Gastrointestinal Bleeding |
| title_full_unstemmed | Taxane-Induced Upper Gastrointestinal Bleeding |
| title_short | Taxane-Induced Upper Gastrointestinal Bleeding |
| title_sort | taxane induced upper gastrointestinal bleeding |
| topic | gastrointestinal bleed chemotherapy breast cancer taxane |
| url | https://www.karger.com/Article/FullText/517818 |
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