Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Infection and viral entry of SARS-CoV-2 crucially depends on the binding of its Spike protein to angiotensin converting enzyme 2 (ACE2) presented on host cells. Glycosylation of both proteins is critical for this interaction. Recombinant soluble human ACE2 can neutralize SARS-CoV-2 and is currently...

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Bibliographic Details
Main Authors: Tümay Capraz, Nikolaus F Kienzl, Elisabeth Laurent, Jan W Perthold, Esther Föderl-Höbenreich, Clemens Grünwald-Gruber, Daniel Maresch, Vanessa Monteil, Janine Niederhöfer, Gerald Wirnsberger, Ali Mirazimi, Kurt Zatloukal, Lukas Mach, Josef M Penninger, Chris Oostenbrink, Johannes Stadlmann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
SARS-CoV-2
angiotensin converting enzyme 2
ACE2
glycosylation
Online Access:https://elifesciences.org/articles/73641

Internet

https://elifesciences.org/articles/73641

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