Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene
Smell strongly contributes to food choice and intake, influencing energy balance and body weight; its reduction or loss has been related to malnutrition problems. Some patients with inflammatory bowel disease (IBD), mainly Crohn’s disease (CD) and ulcerative colitis (UC), are underweight, while othe...
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| author | Giorgia Sollai Melania Melis Mariano Mastinu Danilo Paduano Fabio Chicco Salvatore Magri Paolo Usai Thomas Hummel Iole Tomassini Barbarossa Roberto Crnjar |
| author_facet | Giorgia Sollai Melania Melis Mariano Mastinu Danilo Paduano Fabio Chicco Salvatore Magri Paolo Usai Thomas Hummel Iole Tomassini Barbarossa Roberto Crnjar |
| author_sort | Giorgia Sollai |
| collection | DOAJ |
| description | Smell strongly contributes to food choice and intake, influencing energy balance and body weight; its reduction or loss has been related to malnutrition problems. Some patients with inflammatory bowel disease (IBD), mainly Crohn’s disease (CD) and ulcerative colitis (UC), are underweight, while others are overweight. Some studies suggest that changes in eating habits could be linked to specific disorders of the olfactory functions. We assessed the olfactory performance in 199 subjects (healthy control (HC) <i>n</i> = 99, IBD <i>n</i> = 100), based on the olfactory Threshold, Discrimination and Identification score (TDI score), measured with the “Sniffin’ Sticks” test. Subjects were genotyped for the <i>rs2590498</i> polymorphism of the <i>OBPIIa</i> gene. IBD patients showed both a slightly, but significantly, lower olfactory function and a higher BMI compared to HC subjects. Threshold (in both population) and Discrimination (in IBD patients) olfactory score were affected by the <i>OBPIIa</i> genotype. BMI was influenced by both health status and <i>OBPIIa</i> genotype. A lower olfactory function may delay the satiety sensation and thus increase meal duration and body weight in IBD patients. However, the AA genotype of the <i>OBPIIa</i> seems to “protect” IBD patients from more severe olfactory dysfunction. |
| first_indexed | 2024-03-09T00:38:55Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T00:38:55Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-dbdb1ef9c9ee441ea9d0e1ec9a6389f92023-12-11T18:01:30ZengMDPI AGNutrients2072-66432021-02-0113270310.3390/nu13020703Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) GeneGiorgia Sollai0Melania Melis1Mariano Mastinu2Danilo Paduano3Fabio Chicco4Salvatore Magri5Paolo Usai6Thomas Hummel7Iole Tomassini Barbarossa8Roberto Crnjar9Department of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, Presidio Policlinico of Monserrato, 09042 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, Presidio Policlinico of Monserrato, 09042 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, Presidio Policlinico of Monserrato, 09042 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, Presidio Policlinico of Monserrato, 09042 Cagliari, ItalySmell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01067 Dresden, GermanyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalySmell strongly contributes to food choice and intake, influencing energy balance and body weight; its reduction or loss has been related to malnutrition problems. Some patients with inflammatory bowel disease (IBD), mainly Crohn’s disease (CD) and ulcerative colitis (UC), are underweight, while others are overweight. Some studies suggest that changes in eating habits could be linked to specific disorders of the olfactory functions. We assessed the olfactory performance in 199 subjects (healthy control (HC) <i>n</i> = 99, IBD <i>n</i> = 100), based on the olfactory Threshold, Discrimination and Identification score (TDI score), measured with the “Sniffin’ Sticks” test. Subjects were genotyped for the <i>rs2590498</i> polymorphism of the <i>OBPIIa</i> gene. IBD patients showed both a slightly, but significantly, lower olfactory function and a higher BMI compared to HC subjects. Threshold (in both population) and Discrimination (in IBD patients) olfactory score were affected by the <i>OBPIIa</i> genotype. BMI was influenced by both health status and <i>OBPIIa</i> genotype. A lower olfactory function may delay the satiety sensation and thus increase meal duration and body weight in IBD patients. However, the AA genotype of the <i>OBPIIa</i> seems to “protect” IBD patients from more severe olfactory dysfunction.https://www.mdpi.com/2072-6643/13/2/703smellolfactory dysfunctionCrohn’s disease (CD) and ulcerative colitis (UC)odorant binding proteins (OBPs) geneBMInutrition |
| spellingShingle | Giorgia Sollai Melania Melis Mariano Mastinu Danilo Paduano Fabio Chicco Salvatore Magri Paolo Usai Thomas Hummel Iole Tomassini Barbarossa Roberto Crnjar Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene Nutrients smell olfactory dysfunction Crohn’s disease (CD) and ulcerative colitis (UC) odorant binding proteins (OBPs) gene BMI nutrition |
| title | Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene |
| title_full | Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene |
| title_fullStr | Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene |
| title_full_unstemmed | Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene |
| title_short | Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene |
| title_sort | olfactory function in patients with inflammatory bowel disease ibd is associated with their body mass index and polymorphism in the odor binding protein obpiia gene |
| topic | smell olfactory dysfunction Crohn’s disease (CD) and ulcerative colitis (UC) odorant binding proteins (OBPs) gene BMI nutrition |
| url | https://www.mdpi.com/2072-6643/13/2/703 |
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