Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles
Gitishree Das,1 Han-Seung Shin,2 Jayanta Kumar Patra1 1Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University‐Seoul, Gyeonggi‐do, 10326, Republic of KoreaCorrespondence: Jayan...
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Dove Medical Press
2022-09-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/key-health-benefits-of-korean-ueong-dry-root-extract-combined-silver-n-peer-reviewed-fulltext-article-IJN |
| _version_ | 1811252594573574144 |
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| author | Das G Shin HS Patra JK |
| author_facet | Das G Shin HS Patra JK |
| author_sort | Das G |
| collection | DOAJ |
| description | Gitishree Das,1 Han-Seung Shin,2 Jayanta Kumar Patra1 1Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University‐Seoul, Gyeonggi‐do, 10326, Republic of KoreaCorrespondence: Jayanta Kumar Patra, Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea, Email jkpatra@dongguk.eduIntroduction: Nowadays, in nanotechnology and material science, biosynthesis of the metal nanoparticle is a promising approach.Methods: In the current research, the extract of the Korean Ueong dry root (BdkR), which belongs to the Asteraceae family, was used as a reducing and capping agent, for the green synthesis of the BdkR-Ag nanoparticles in a cost-effective and highly efficient manner. In this study for the reaction measures, UV-Vis spectroscopy was applied. SEM, EDX, FTIR, XRD, mean size distribution, and zeta potential were used for the characterization of the green synthesized BdkR-AgNPs. In the beginning, the primary phytochemical screening of BdkR extract was estimated and the cytotoxicity, antidiabetic, antioxidant, and antibacterial activities of the green synthesized BdkR-AgNPs were evaluated.Results: According to the results, the BdkR extract is rich in various phytochemicals and the generated AgNPs were crystalline in nature. The surface plasmon resonance value of the BdkR-AgNPs was 444 nm confirming the synthesis of AgNPs. The BdkR-AgNPs displayed four clear diffraction peaks at 2 theta angles (38.22); (46.15); (64.88); (76.83), respectively, which are equivalent to (111), (200), (220) and (311). The obtained nanoparticles have a zeta potential of − 17.0 mV. Furthermore, the generated BdkR-AgNPs exhibited considerable antidiabetic effect in terms of the inhibition of α-glucosidase with a maximum inhibition value of 95.41% at 5.0 μg/mL and more than 86% inhibition at 2.5 μg/mL and the estimated IC50 value was found to be 0.653 μg/mL. Further, it also displayed a significant cytotoxicity activity against the HepG2 cancer cell lines at 10 μg/mL and 100 μg/mL concentrations with 86% and 88% of inhibition, respectively. Besides this, the synthesized AgNPs also displayed promising antioxidant activities in terms of the DPPH (IC50 value - 56.26 μg/mL), ABTS (IC50 value - 171.43 μg/mL) and reducing power (IC0.5 value - 227.42 μg/mL).Discussion: The multipotential effects of the synthesized BdkR-AgNPs might be attributed to the presence of the bioactive compounds in the BdkR extract that acted as the capping and reducing agent in the synthesis process. The green synthesized BdkR-AgNPs exhibited promising bioactive potential for their future applications in the food and biomedical field.Keywords: antidiabetic, antioxidant, cytotoxicity, silver nanoparticle, green synthesis |
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| format | Article |
| id | doaj.art-dbdc02591af549d88307dfe80050ed1d |
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| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-04-12T16:38:00Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
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| series | International Journal of Nanomedicine |
| spelling | doaj.art-dbdc02591af549d88307dfe80050ed1d2022-12-22T03:24:56ZengDove Medical PressInternational Journal of Nanomedicine1178-20132022-09-01Volume 174261427578260Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver NanoparticlesDas GShin HSPatra JKGitishree Das,1 Han-Seung Shin,2 Jayanta Kumar Patra1 1Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University‐Seoul, Gyeonggi‐do, 10326, Republic of KoreaCorrespondence: Jayanta Kumar Patra, Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea, Email jkpatra@dongguk.eduIntroduction: Nowadays, in nanotechnology and material science, biosynthesis of the metal nanoparticle is a promising approach.Methods: In the current research, the extract of the Korean Ueong dry root (BdkR), which belongs to the Asteraceae family, was used as a reducing and capping agent, for the green synthesis of the BdkR-Ag nanoparticles in a cost-effective and highly efficient manner. In this study for the reaction measures, UV-Vis spectroscopy was applied. SEM, EDX, FTIR, XRD, mean size distribution, and zeta potential were used for the characterization of the green synthesized BdkR-AgNPs. In the beginning, the primary phytochemical screening of BdkR extract was estimated and the cytotoxicity, antidiabetic, antioxidant, and antibacterial activities of the green synthesized BdkR-AgNPs were evaluated.Results: According to the results, the BdkR extract is rich in various phytochemicals and the generated AgNPs were crystalline in nature. The surface plasmon resonance value of the BdkR-AgNPs was 444 nm confirming the synthesis of AgNPs. The BdkR-AgNPs displayed four clear diffraction peaks at 2 theta angles (38.22); (46.15); (64.88); (76.83), respectively, which are equivalent to (111), (200), (220) and (311). The obtained nanoparticles have a zeta potential of − 17.0 mV. Furthermore, the generated BdkR-AgNPs exhibited considerable antidiabetic effect in terms of the inhibition of α-glucosidase with a maximum inhibition value of 95.41% at 5.0 μg/mL and more than 86% inhibition at 2.5 μg/mL and the estimated IC50 value was found to be 0.653 μg/mL. Further, it also displayed a significant cytotoxicity activity against the HepG2 cancer cell lines at 10 μg/mL and 100 μg/mL concentrations with 86% and 88% of inhibition, respectively. Besides this, the synthesized AgNPs also displayed promising antioxidant activities in terms of the DPPH (IC50 value - 56.26 μg/mL), ABTS (IC50 value - 171.43 μg/mL) and reducing power (IC0.5 value - 227.42 μg/mL).Discussion: The multipotential effects of the synthesized BdkR-AgNPs might be attributed to the presence of the bioactive compounds in the BdkR extract that acted as the capping and reducing agent in the synthesis process. The green synthesized BdkR-AgNPs exhibited promising bioactive potential for their future applications in the food and biomedical field.Keywords: antidiabetic, antioxidant, cytotoxicity, silver nanoparticle, green synthesishttps://www.dovepress.com/key-health-benefits-of-korean-ueong-dry-root-extract-combined-silver-n-peer-reviewed-fulltext-article-IJNantidiabeticantioxidantcytotoxicitysilver nanoparticlegreen synthesis |
| spellingShingle | Das G Shin HS Patra JK Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles International Journal of Nanomedicine antidiabetic antioxidant cytotoxicity silver nanoparticle green synthesis |
| title | Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles |
| title_full | Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles |
| title_fullStr | Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles |
| title_full_unstemmed | Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles |
| title_short | Key Health Benefits of Korean Ueong Dry Root Extract Combined Silver Nanoparticles |
| title_sort | key health benefits of korean ueong dry root extract combined silver nanoparticles |
| topic | antidiabetic antioxidant cytotoxicity silver nanoparticle green synthesis |
| url | https://www.dovepress.com/key-health-benefits-of-korean-ueong-dry-root-extract-combined-silver-n-peer-reviewed-fulltext-article-IJN |
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