Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8<sup>+</sup> T-Cell Dysfunction

Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8<sup>+</sup> T-Cell Dysfunction

Chronic hepatitis C virus (HCV) infection causes generalized CD8<sup>+</sup> T cell impairment, not limited to HCV-specific CD8<sup>+</sup> T-cells. Liver-infiltrating monocyte-derived macrophages (MDMs) contribute to the local micro-environment and can interact with and infl...

Full description

Bibliographic Details
Main Authors: Faria Ahmed, Andrea Ibrahim, Curtis L. Cooper, Ashok Kumar, Angela M. Crawley
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
macrophages
CD8<sup>+</sup> T-cells
monocyte-derived macrophages
hepatitis C virus
interferon-γ
Online Access:https://www.mdpi.com/2073-4409/8/4/374

Internet

https://www.mdpi.com/2073-4409/8/4/374

Similar Items