Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms
Polymethoxyflavones (PMFs) are dietary bioactive phytochemicals, naturally present in all forms of citrus or plants. For this updated review, the specialized databases of PubMed and Web of Science were researched using keywords such as “polymethoxy flavones,” “pharmacology,” “molecular mechanisms,”...
| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Articolo |
| Lingua: | English |
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Taylor & Francis Group
2023-09-01
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| Serie: | International Journal of Food Properties |
| Soggetti: | |
| Accesso online: | https://www.tandfonline.com/doi/10.1080/10942912.2023.2189568 |
| _version_ | 1826908930956066816 |
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| author | Zarina Mushtaq Mahwish Aslam Muhammad Imran Mohamed A. Abdelgawad Farhan Saeed Tara Khursheed Maryam Umar Waleed Al Abdulmonem Ahmed H. Al Ghorab Suliman A. Alsagaby Tabussam Tufail Muhammad Ahtisham Raza Muzzamal Hussain Entessar Al JBawi |
| author_facet | Zarina Mushtaq Mahwish Aslam Muhammad Imran Mohamed A. Abdelgawad Farhan Saeed Tara Khursheed Maryam Umar Waleed Al Abdulmonem Ahmed H. Al Ghorab Suliman A. Alsagaby Tabussam Tufail Muhammad Ahtisham Raza Muzzamal Hussain Entessar Al JBawi |
| author_sort | Zarina Mushtaq |
| collection | DOAJ |
| description | Polymethoxyflavones (PMFs) are dietary bioactive phytochemicals, naturally present in all forms of citrus or plants. For this updated review, the specialized databases of PubMed and Web of Science were researched using keywords such as “polymethoxy flavones,” “pharmacology,” “molecular mechanisms,” “signaling pathways,” and “therapeutic applications.” The most prominent citrus PMFs with proven pharmacological effects are tangeretin, nobiletin, 5′-demethylnobiletin, tetramethyl-o-scutellarein, pentamethoxyflavone, tetramethyl-o-isoscutellarein, and sinensetine. The results of in vivo and in vitro preclinical studies of PMFs have highlighted molecular mechanisms and signaling pathways for anti-inflammatory, anti-cancer, chemopreventive, antidiabetic, anti-obesity, hepatoprotective and neuroprotective effects in neurodegenerative diseases. The results of the studies support the traditional effects of PMFs and therefore it is necessary that these natural compounds be further investigated in clinical trials. PMFs should be designed and formulated in nanoformulations that increase their bioavailability and transport them precisely to the target in order to increase their therapeutic effects. |
| first_indexed | 2024-03-11T18:20:32Z |
| format | Article |
| id | doaj.art-dbdd2e41f09f4cbda82c2094175bde9d |
| institution | Directory Open Access Journal |
| issn | 1094-2912 1532-2386 |
| language | English |
| last_indexed | 2025-02-17T09:31:54Z |
| publishDate | 2023-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj.art-dbdd2e41f09f4cbda82c2094175bde9d2025-01-02T10:41:34ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862023-09-0126186689310.1080/10942912.2023.2189568Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanismsZarina Mushtaq0Mahwish Aslam1Muhammad Imran2Mohamed A. Abdelgawad3Farhan Saeed4Tara Khursheed5Maryam Umar6Waleed Al Abdulmonem7Ahmed H. Al Ghorab8Suliman A. Alsagaby9Tabussam Tufail10Muhammad Ahtisham Raza11Muzzamal Hussain12Entessar Al JBawi13Department of Food Sciences, Government College University Faisalabad, Faisalabad, PakistanFaculty of Allied Health Sciences, University Institute of Diet and Nutritional Sciences, Lahore, PakistanDepartment of Food Science and Technology, University of Narowal-Pakistan, Narowal, PakistanDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Food Sciences, Government College University Faisalabad, Faisalabad, PakistanDepartment of Nutrition and Dietetics, National University of Medical Sciences (NUMS), Rawalpindi, PakistanDepartment of Food Sciences, Government College University Faisalabad, Faisalabad, PakistanDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Saudi ArabiaDepartment of Chemistry, College of Science, Jouf University, Sakaka, Saudi ArabiaDepartment of Medical Laboratory sciences, College of Applied Medical Sciences, Majmaah University, AI Majmaah, Saudi ArabiaUniversity Institute of Diet & Nutritional Sciences, the University of Lahore, Lahore, PakistanDepartment of Food Sciences, Government College University Faisalabad, Faisalabad, PakistanDepartment of Food Sciences, Government College University Faisalabad, Faisalabad, PakistanAgricultural Extension Directorate, MAAR, Damascus, SyriaPolymethoxyflavones (PMFs) are dietary bioactive phytochemicals, naturally present in all forms of citrus or plants. For this updated review, the specialized databases of PubMed and Web of Science were researched using keywords such as “polymethoxy flavones,” “pharmacology,” “molecular mechanisms,” “signaling pathways,” and “therapeutic applications.” The most prominent citrus PMFs with proven pharmacological effects are tangeretin, nobiletin, 5′-demethylnobiletin, tetramethyl-o-scutellarein, pentamethoxyflavone, tetramethyl-o-isoscutellarein, and sinensetine. The results of in vivo and in vitro preclinical studies of PMFs have highlighted molecular mechanisms and signaling pathways for anti-inflammatory, anti-cancer, chemopreventive, antidiabetic, anti-obesity, hepatoprotective and neuroprotective effects in neurodegenerative diseases. The results of the studies support the traditional effects of PMFs and therefore it is necessary that these natural compounds be further investigated in clinical trials. PMFs should be designed and formulated in nanoformulations that increase their bioavailability and transport them precisely to the target in order to increase their therapeutic effects.https://www.tandfonline.com/doi/10.1080/10942912.2023.2189568Polymethoxyflavonespharmacological effectsmolecular mechanismssignaling pathwaystoxicityclinical studies |
| spellingShingle | Zarina Mushtaq Mahwish Aslam Muhammad Imran Mohamed A. Abdelgawad Farhan Saeed Tara Khursheed Maryam Umar Waleed Al Abdulmonem Ahmed H. Al Ghorab Suliman A. Alsagaby Tabussam Tufail Muhammad Ahtisham Raza Muzzamal Hussain Entessar Al JBawi Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms International Journal of Food Properties Polymethoxyflavones pharmacological effects molecular mechanisms signaling pathways toxicity clinical studies |
| title | Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms |
| title_full | Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms |
| title_fullStr | Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms |
| title_full_unstemmed | Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms |
| title_short | Polymethoxyflavones: an updated review on pharmacological properties and underlying molecular mechanisms |
| title_sort | polymethoxyflavones an updated review on pharmacological properties and underlying molecular mechanisms |
| topic | Polymethoxyflavones pharmacological effects molecular mechanisms signaling pathways toxicity clinical studies |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2023.2189568 |
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