Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations
Tubeimoside-1 (TBMS-1), a natural triterpenoid saponin found in traditional Chinese herbal medicine Bolbostemmatis Rhizoma, is present in numerous Chinese medicine preparations. This review aims to comprehensively describe the pharmacology, pharmacokinetics, toxicity and targeting preparations of TB...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.941270/full |
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| author | Chang-Lin Wang Chang-Lin Wang Ming-Zhou Gao Ming-Zhou Gao Dong-Mei Gao Dong-Mei Gao Ying-Hui Guo Ying-Hui Guo Zhan Gao Zhan Gao Xiang-Ju Gao Xiang-Ju Gao Jie-Qiong Wang Jie-Qiong Wang Ming-Qi Qiao Ming-Qi Qiao |
| author_facet | Chang-Lin Wang Chang-Lin Wang Ming-Zhou Gao Ming-Zhou Gao Dong-Mei Gao Dong-Mei Gao Ying-Hui Guo Ying-Hui Guo Zhan Gao Zhan Gao Xiang-Ju Gao Xiang-Ju Gao Jie-Qiong Wang Jie-Qiong Wang Ming-Qi Qiao Ming-Qi Qiao |
| author_sort | Chang-Lin Wang |
| collection | DOAJ |
| description | Tubeimoside-1 (TBMS-1), a natural triterpenoid saponin found in traditional Chinese herbal medicine Bolbostemmatis Rhizoma, is present in numerous Chinese medicine preparations. This review aims to comprehensively describe the pharmacology, pharmacokinetics, toxicity and targeting preparations of TBMS-1, as well the therapeutic potential for cancer treatement. Information concerning TBMS-1 was systematically collected from the authoritative internet database of PubMed, Web of Science, and China National Knowledge Infrastructure applying a combination of keywords involving “tumor,” “pharmacokinetics,” “toxicology,” and targeting preparations. New evidence shows that TBMS-1 possesses a remarkable inhibitory effect on the tumors of the respiratory system, digestive system, nervous system, genital system as well as other systems in vivo and in vitro. Pharmacokinetic studies reveal that TBMS-1 is extensively distributed in various tissues and prone to degradation by the gastrointestinal tract after oral administration, causing a decrease in bioavailability. Meanwhile, several lines of evidence have shown that TBMS-1 may cause adverse and toxic effects at high doses. The development of liver-targeting and lung-targeting preparations can reduce the toxic effect of TBMS-1 and increase its efficacy. In summary, TBMS-1 can effectively control tumor treatment. However, additional research is necessary to investigate in vivo antitumor effects and the pharmacokinetics of TBMS-1. In addition, to reduce the toxicity of TBMS-1, future research should aim to modify its structure, formulate targeting preparations or combinations with other drugs. |
| first_indexed | 2024-12-11T17:03:37Z |
| format | Article |
| id | doaj.art-dbdd7867e5d54099aa4e2591998643e3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T17:03:37Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-dbdd7867e5d54099aa4e2591998643e32022-12-22T00:57:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-07-011310.3389/fphar.2022.941270941270Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparationsChang-Lin Wang0Chang-Lin Wang1Ming-Zhou Gao2Ming-Zhou Gao3Dong-Mei Gao4Dong-Mei Gao5Ying-Hui Guo6Ying-Hui Guo7Zhan Gao8Zhan Gao9Xiang-Ju Gao10Xiang-Ju Gao11Jie-Qiong Wang12Jie-Qiong Wang13Ming-Qi Qiao14Ming-Qi Qiao15School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaInstitute of Traditional Chinese Medicine Innovation, Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaResearch and Innovation Team of Emotional Diseases and Syndromes in Shandong University of Traditional Chinese Medicine, Jinan, ChinaTubeimoside-1 (TBMS-1), a natural triterpenoid saponin found in traditional Chinese herbal medicine Bolbostemmatis Rhizoma, is present in numerous Chinese medicine preparations. This review aims to comprehensively describe the pharmacology, pharmacokinetics, toxicity and targeting preparations of TBMS-1, as well the therapeutic potential for cancer treatement. Information concerning TBMS-1 was systematically collected from the authoritative internet database of PubMed, Web of Science, and China National Knowledge Infrastructure applying a combination of keywords involving “tumor,” “pharmacokinetics,” “toxicology,” and targeting preparations. New evidence shows that TBMS-1 possesses a remarkable inhibitory effect on the tumors of the respiratory system, digestive system, nervous system, genital system as well as other systems in vivo and in vitro. Pharmacokinetic studies reveal that TBMS-1 is extensively distributed in various tissues and prone to degradation by the gastrointestinal tract after oral administration, causing a decrease in bioavailability. Meanwhile, several lines of evidence have shown that TBMS-1 may cause adverse and toxic effects at high doses. The development of liver-targeting and lung-targeting preparations can reduce the toxic effect of TBMS-1 and increase its efficacy. In summary, TBMS-1 can effectively control tumor treatment. However, additional research is necessary to investigate in vivo antitumor effects and the pharmacokinetics of TBMS-1. In addition, to reduce the toxicity of TBMS-1, future research should aim to modify its structure, formulate targeting preparations or combinations with other drugs.https://www.frontiersin.org/articles/10.3389/fphar.2022.941270/fulltubeimoside-1antitumorpharmacokineticstoxicitytargeting preparations |
| spellingShingle | Chang-Lin Wang Chang-Lin Wang Ming-Zhou Gao Ming-Zhou Gao Dong-Mei Gao Dong-Mei Gao Ying-Hui Guo Ying-Hui Guo Zhan Gao Zhan Gao Xiang-Ju Gao Xiang-Ju Gao Jie-Qiong Wang Jie-Qiong Wang Ming-Qi Qiao Ming-Qi Qiao Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations Frontiers in Pharmacology tubeimoside-1 antitumor pharmacokinetics toxicity targeting preparations |
| title | Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations |
| title_full | Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations |
| title_fullStr | Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations |
| title_full_unstemmed | Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations |
| title_short | Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations |
| title_sort | tubeimoside 1 a review of its antitumor effects pharmacokinetics toxicity and targeting preparations |
| topic | tubeimoside-1 antitumor pharmacokinetics toxicity targeting preparations |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.941270/full |
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