No association between telomere length and osteonecrosis of the femoral head
Abstract Background Telemore length (TL) shortening has been found in many diseases. However, clinical characteristics of TL shortening in osteonecrosis of the femoral head (ONFH) has not been investigated. Therefore, we studied whether TL changes have clinicopathological values in ONFH. Methods The...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-021-04047-5 |
| _version_ | 1818393651544326144 |
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| author | Si-Wook Lee Kyung-Hwan Lim Kyung-Jae Lee Yu-Ran Heo Jae-Ho Lee |
| author_facet | Si-Wook Lee Kyung-Hwan Lim Kyung-Jae Lee Yu-Ran Heo Jae-Ho Lee |
| author_sort | Si-Wook Lee |
| collection | DOAJ |
| description | Abstract Background Telemore length (TL) shortening has been found in many diseases. However, clinical characteristics of TL shortening in osteonecrosis of the femoral head (ONFH) has not been investigated. Therefore, we studied whether TL changes have clinicopathological values in ONFH. Methods The TL in the synovial tissues of 36 ONFH and 127 control patients (femoral neck fracture) was examined by quantitative real-time PCR as relative length, Δ Ct value. In addition, the correlation between TL and clinical features of ONFH and controls was analyzed. Results The average TL in the femoral tissues was 1.46 ± 3.12 (standard deviation). The average TL in the ONFH and control tissues was 1.92 ± 4.11 and 1.34 ± 2.78, respectively, however, the difference was absent (p = 0.324). Furthermore, a shorter TL was tended to be associated with erythrocyte sedimentation rate (100% vs. 61.5%, p = 0.073); however, the association was not statistically significant. Conclusions In this study, we demonstrated that there is no association between the TL and clinicopathologic characteristics of ONFH patients. However, further studies considering the genetic factors are needed to be performed. |
| first_indexed | 2024-12-14T05:48:42Z |
| format | Article |
| id | doaj.art-dbdddf7ae7114ea3a2f1b4c95d3a3827 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-14T05:48:42Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-dbdddf7ae7114ea3a2f1b4c95d3a38272022-12-21T23:14:48ZengBMCBMC Musculoskeletal Disorders1471-24742021-02-012211510.1186/s12891-021-04047-5No association between telomere length and osteonecrosis of the femoral headSi-Wook Lee0Kyung-Hwan Lim1Kyung-Jae Lee2Yu-Ran Heo3Jae-Ho Lee4Department of Orthopaedic Surgery, Keimyung University School of MedicineDepartment of Orthopaedic Surgery, Keimyung University School of MedicineDepartment of Orthopaedic Surgery, Keimyung University School of MedicineDepartment of Anatomy, Keimyung University School of MedicineDepartment of Anatomy, Keimyung University School of MedicineAbstract Background Telemore length (TL) shortening has been found in many diseases. However, clinical characteristics of TL shortening in osteonecrosis of the femoral head (ONFH) has not been investigated. Therefore, we studied whether TL changes have clinicopathological values in ONFH. Methods The TL in the synovial tissues of 36 ONFH and 127 control patients (femoral neck fracture) was examined by quantitative real-time PCR as relative length, Δ Ct value. In addition, the correlation between TL and clinical features of ONFH and controls was analyzed. Results The average TL in the femoral tissues was 1.46 ± 3.12 (standard deviation). The average TL in the ONFH and control tissues was 1.92 ± 4.11 and 1.34 ± 2.78, respectively, however, the difference was absent (p = 0.324). Furthermore, a shorter TL was tended to be associated with erythrocyte sedimentation rate (100% vs. 61.5%, p = 0.073); however, the association was not statistically significant. Conclusions In this study, we demonstrated that there is no association between the TL and clinicopathologic characteristics of ONFH patients. However, further studies considering the genetic factors are needed to be performed.https://doi.org/10.1186/s12891-021-04047-5Telomere lengthONFHOsteonecrosisErythrocyte sedimentation rateFemoral head |
| spellingShingle | Si-Wook Lee Kyung-Hwan Lim Kyung-Jae Lee Yu-Ran Heo Jae-Ho Lee No association between telomere length and osteonecrosis of the femoral head BMC Musculoskeletal Disorders Telomere length ONFH Osteonecrosis Erythrocyte sedimentation rate Femoral head |
| title | No association between telomere length and osteonecrosis of the femoral head |
| title_full | No association between telomere length and osteonecrosis of the femoral head |
| title_fullStr | No association between telomere length and osteonecrosis of the femoral head |
| title_full_unstemmed | No association between telomere length and osteonecrosis of the femoral head |
| title_short | No association between telomere length and osteonecrosis of the femoral head |
| title_sort | no association between telomere length and osteonecrosis of the femoral head |
| topic | Telomere length ONFH Osteonecrosis Erythrocyte sedimentation rate Femoral head |
| url | https://doi.org/10.1186/s12891-021-04047-5 |
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