Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modi...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-10-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/13/10/13624 |
| _version_ | 1811305794250997760 |
|---|---|
| author | Wei Duan Lingxue Kong Santanu Bhattacharya ChunGuang Li Yimin Zhu Shu-Feng Zhou Ming Wei Liang Qiao Hadi Al.Shamaileh Sarah Shigdar Joanna Macdonald Michael O'Connor Tao Wang Dongxi Xiang |
| author_facet | Wei Duan Lingxue Kong Santanu Bhattacharya ChunGuang Li Yimin Zhu Shu-Feng Zhou Ming Wei Liang Qiao Hadi Al.Shamaileh Sarah Shigdar Joanna Macdonald Michael O'Connor Tao Wang Dongxi Xiang |
| author_sort | Wei Duan |
| collection | DOAJ |
| description | Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents. |
| first_indexed | 2024-04-13T08:32:45Z |
| format | Article |
| id | doaj.art-dbdf1dac744d4be0adf0a0aa8c7beb25 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T08:32:45Z |
| publishDate | 2013-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-dbdf1dac744d4be0adf0a0aa8c7beb252022-12-22T02:54:13ZengMDPI AGSensors1424-82202013-10-011310136241363710.3390/s131013624Aptamers as Theranostic Agents: Modifications, Serum Stability and FunctionalisationWei DuanLingxue KongSantanu BhattacharyaChunGuang LiYimin ZhuShu-Feng ZhouMing WeiLiang QiaoHadi Al.ShamailehSarah ShigdarJoanna MacdonaldMichael O'ConnorTao WangDongxi XiangAptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.http://www.mdpi.com/1424-8220/13/10/13624aptamerSELEXcancerdiagnosticslocked nucleic acidunlocked nucleic acid |
| spellingShingle | Wei Duan Lingxue Kong Santanu Bhattacharya ChunGuang Li Yimin Zhu Shu-Feng Zhou Ming Wei Liang Qiao Hadi Al.Shamaileh Sarah Shigdar Joanna Macdonald Michael O'Connor Tao Wang Dongxi Xiang Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation Sensors aptamer SELEX cancer diagnostics locked nucleic acid unlocked nucleic acid |
| title | Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation |
| title_full | Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation |
| title_fullStr | Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation |
| title_full_unstemmed | Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation |
| title_short | Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation |
| title_sort | aptamers as theranostic agents modifications serum stability and functionalisation |
| topic | aptamer SELEX cancer diagnostics locked nucleic acid unlocked nucleic acid |
| url | http://www.mdpi.com/1424-8220/13/10/13624 |
| work_keys_str_mv | AT weiduan aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT lingxuekong aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT santanubhattacharya aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT chunguangli aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT yiminzhu aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT shufengzhou aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT mingwei aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT liangqiao aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT hadialshamaileh aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT sarahshigdar aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT joannamacdonald aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT michaelo039connor aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT taowang aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation AT dongxixiang aptamersastheranosticagentsmodificationsserumstabilityandfunctionalisation |