Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells
Pancreas ductal adenocarcinoma is one of the deadliest cancers where surgery remains the main survival factor. Mitochondria were described to be involved in tumor aggressiveness in several cancer types including pancreas cancer. We have previously reported that myoferlin controls mitochondrial struc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1643 |
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| author | Sandy Anania Raphaël Peiffer Gilles Rademaker Alexandre Hego Marc Thiry Louise Deldicque Marc Francaux Naïma Maloujahmoum Ferman Agirman Akeila Bellahcène Vincent Castronovo Olivier Peulen |
| author_facet | Sandy Anania Raphaël Peiffer Gilles Rademaker Alexandre Hego Marc Thiry Louise Deldicque Marc Francaux Naïma Maloujahmoum Ferman Agirman Akeila Bellahcène Vincent Castronovo Olivier Peulen |
| author_sort | Sandy Anania |
| collection | DOAJ |
| description | Pancreas ductal adenocarcinoma is one of the deadliest cancers where surgery remains the main survival factor. Mitochondria were described to be involved in tumor aggressiveness in several cancer types including pancreas cancer. We have previously reported that myoferlin controls mitochondrial structure and function, and demonstrated that myoferlin depletion disturbs the mitochondrial dynamics culminating in a mitochondrial fission. In order to unravel the mechanism underlying this observation, we explored the myoferlin localization in pancreatic cancer cells and showed a colocalization with the mitochondrial dynamic machinery element: mitofusin. This colocalization was confirmed in several pancreas cancer cell lines and in normal cell lines as well. Moreover, in pancreas cancer cell lines, it appeared that myoferlin interacted with mitofusin. These discoveries open-up new research avenues aiming at modulating mitofusin function in pancreas cancer. |
| first_indexed | 2024-03-10T18:59:41Z |
| format | Article |
| id | doaj.art-dbe0c9e9149e47b19a2308a3a85c500e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:59:41Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dbe0c9e9149e47b19a2308a3a85c500e2023-11-20T04:31:46ZengMDPI AGCancers2072-66942020-06-01126164310.3390/cancers12061643Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer CellsSandy Anania0Raphaël Peiffer1Gilles Rademaker2Alexandre Hego3Marc Thiry4Louise Deldicque5Marc Francaux6Naïma Maloujahmoum7Ferman Agirman8Akeila Bellahcène9Vincent Castronovo10Olivier Peulen11Metastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumMetastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumMetastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumImaging Facilities, GIGA-Research, GIGA-Institute B36, University of Liège, B-4000 Liège, BelgiumLaboratory of Cellular and Tissular Biology, GIGA-Neurosciences, Cell Biology L3, University of Liège, B-4000 Liège, BelgiumInstitute of Neuroscience, Université catholique de Louvain, B-1348 Louvain-la-Neuve, BelgiumInstitute of Neuroscience, Université catholique de Louvain, B-1348 Louvain-la-Neuve, BelgiumMetastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumMetastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumMetastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumMetastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumMetastasis Research Laboratory (MRL), GIGA-Cancer, Pathology Institute B23, University of Liège, B-4000 Liège, BelgiumPancreas ductal adenocarcinoma is one of the deadliest cancers where surgery remains the main survival factor. Mitochondria were described to be involved in tumor aggressiveness in several cancer types including pancreas cancer. We have previously reported that myoferlin controls mitochondrial structure and function, and demonstrated that myoferlin depletion disturbs the mitochondrial dynamics culminating in a mitochondrial fission. In order to unravel the mechanism underlying this observation, we explored the myoferlin localization in pancreatic cancer cells and showed a colocalization with the mitochondrial dynamic machinery element: mitofusin. This colocalization was confirmed in several pancreas cancer cell lines and in normal cell lines as well. Moreover, in pancreas cancer cell lines, it appeared that myoferlin interacted with mitofusin. These discoveries open-up new research avenues aiming at modulating mitofusin function in pancreas cancer.https://www.mdpi.com/2072-6694/12/6/1643myoferlinmitochondriamitofusinpancreas cancer |
| spellingShingle | Sandy Anania Raphaël Peiffer Gilles Rademaker Alexandre Hego Marc Thiry Louise Deldicque Marc Francaux Naïma Maloujahmoum Ferman Agirman Akeila Bellahcène Vincent Castronovo Olivier Peulen Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells Cancers myoferlin mitochondria mitofusin pancreas cancer |
| title | Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells |
| title_full | Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells |
| title_fullStr | Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells |
| title_full_unstemmed | Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells |
| title_short | Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells |
| title_sort | myoferlin is a yet unknown interactor of the mitochondrial dynamics machinery in pancreas cancer cells |
| topic | myoferlin mitochondria mitofusin pancreas cancer |
| url | https://www.mdpi.com/2072-6694/12/6/1643 |
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