Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center
In half of the suspected autoimmune encephalitis (AIE) patients, no antibodies are identified despite extensive investigation. Therapeutic plasma exchange (TPE) is a potential first-line therapy for various subtypes of AIE. Here, we present a case of autoantibody-negative-suspected AIE, managed succ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2018;volume=12;issue=2;spage=173;epage=175;aulast=Pandey |
| _version_ | 1819267323622588416 |
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| author | Prashant Kumar Pandey Nitin Agarwal Manish Gupta |
| author_facet | Prashant Kumar Pandey Nitin Agarwal Manish Gupta |
| author_sort | Prashant Kumar Pandey |
| collection | DOAJ |
| description | In half of the suspected autoimmune encephalitis (AIE) patients, no antibodies are identified despite extensive investigation. Therapeutic plasma exchange (TPE) is a potential first-line therapy for various subtypes of AIE. Here, we present a case of autoantibody-negative-suspected AIE, managed successfully with TPE after patient showed no response to steroids. A total of 5 sessions of TPE was done. One standard TPE procedure session was 1.2–1.5 plasma volume exchanges using 5% albumin as a replacement fluid. After five sessions, patient's clinical condition improved significantly, and a repeated magnetic resonance imaging after 5th cycle of TPE revealed a reduction in the areas of signal alteration. This was suggestive of regression of disease. Patient was discharged on 10th day of hospital admission. With early suspicion even in the absence of detectable autoantibodies, TPE plays an important role in the management of encephalitis. |
| first_indexed | 2024-12-23T21:15:21Z |
| format | Article |
| id | doaj.art-dbe11f0c11164e0598b757932a76ac53 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-23T21:15:21Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-dbe11f0c11164e0598b757932a76ac532022-12-21T17:30:55ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652018-01-0112217317510.4103/ajts.AJTS_112_17Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care centerPrashant Kumar PandeyNitin AgarwalManish GuptaIn half of the suspected autoimmune encephalitis (AIE) patients, no antibodies are identified despite extensive investigation. Therapeutic plasma exchange (TPE) is a potential first-line therapy for various subtypes of AIE. Here, we present a case of autoantibody-negative-suspected AIE, managed successfully with TPE after patient showed no response to steroids. A total of 5 sessions of TPE was done. One standard TPE procedure session was 1.2–1.5 plasma volume exchanges using 5% albumin as a replacement fluid. After five sessions, patient's clinical condition improved significantly, and a repeated magnetic resonance imaging after 5th cycle of TPE revealed a reduction in the areas of signal alteration. This was suggestive of regression of disease. Patient was discharged on 10th day of hospital admission. With early suspicion even in the absence of detectable autoantibodies, TPE plays an important role in the management of encephalitis.http://www.ajts.org/article.asp?issn=0973-6247;year=2018;volume=12;issue=2;spage=173;epage=175;aulast=PandeyAutoimmune encephalitiscorticosteroidintravenous immunoglobulinstherapeutic plasma exchange |
| spellingShingle | Prashant Kumar Pandey Nitin Agarwal Manish Gupta Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center Asian Journal of Transfusion Science Autoimmune encephalitis corticosteroid intravenous immunoglobulins therapeutic plasma exchange |
| title | Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center |
| title_full | Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center |
| title_fullStr | Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center |
| title_full_unstemmed | Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center |
| title_short | Therapeutic plasma exchange as a life-saving therapy in a suspected case of autoimmune encephalitis: A case report from a tertiary health-care center |
| title_sort | therapeutic plasma exchange as a life saving therapy in a suspected case of autoimmune encephalitis a case report from a tertiary health care center |
| topic | Autoimmune encephalitis corticosteroid intravenous immunoglobulins therapeutic plasma exchange |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2018;volume=12;issue=2;spage=173;epage=175;aulast=Pandey |
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