Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital
Objectives: A world without effective antibiotics is a terrifying but a real prospect. Overuse or misuse especially of newer and higher antimicrobials (AM) is of particular concern, as this contributes to development of resistance among microorganisms. To check this trend, the Reserve Drug Inden...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5593/10974_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_.pdf |
| Summary: | Objectives: A world without effective antibiotics is a terrifying but
a real prospect. Overuse or misuse especially of newer and higher
antimicrobials (AM) is of particular concern, as this contributes to
development of resistance among microorganisms. To check this
trend, the Reserve Drug Indent Form (RDIF) was introduced in
our hospital and its impact on AM consumption, cost of therapy
and the sensitivity pattern was studied in the medical intensive
care unit (MICU).
Materials and Methods: A retrospective descriptive study in the
medical ICU of a tertiary care hospital from July 2012 to August
2013. From March 2013, RDIF was made mandatory to be filled
up prior to prescribing reserve antimicrobials. AM consumption
(expressed as DDD/100 bed days) and sensitivity pattern
(expressed in percentage) six months prior to and six months
after implementation of the form were analysed.
Results: The total Reserve AM consumption was 125.79 per
100 bed days during the study period. Average occupancy
index was 0.50 and length of ICU stay was 6 days. The total
consumption reduced from 85.55/100 to 40.24/100 bed days
after the introduction of the RDIF. However, Imipenem usage
increased from 11.35/100 to 23.94/100 bed days, which can be
attributed to sensitivity profile to Imipenem (82.1%) compared to
Meropenem (65.7%). Cost of therapy reduced from Rs 6,27,951
to 4,20,469.
Conclusion: Reserve AM consumption showed a declining trend
after introduction of the RDIF. Hence, the RDIF served as an
important tool to combat inappropriate use, reducing the cost
burden and also helped to improve the sensitivity to reserve
drugs. |
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| ISSN: | 2249-782X 0973-709X |