Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital
Objectives: A world without effective antibiotics is a terrifying but a real prospect. Overuse or misuse especially of newer and higher antimicrobials (AM) is of particular concern, as this contributes to development of resistance among microorganisms. To check this trend, the Reserve Drug Inden...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5593/10974_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_.pdf |
| _version_ | 1819157936446898176 |
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| author | Deepthi Shridhar P. Anitha K.B. Mohandas Rai Anisha Fernandes |
| author_facet | Deepthi Shridhar P. Anitha K.B. Mohandas Rai Anisha Fernandes |
| author_sort | Deepthi Shridhar P. |
| collection | DOAJ |
| description | Objectives: A world without effective antibiotics is a terrifying but
a real prospect. Overuse or misuse especially of newer and higher
antimicrobials (AM) is of particular concern, as this contributes to
development of resistance among microorganisms. To check this
trend, the Reserve Drug Indent Form (RDIF) was introduced in
our hospital and its impact on AM consumption, cost of therapy
and the sensitivity pattern was studied in the medical intensive
care unit (MICU).
Materials and Methods: A retrospective descriptive study in the
medical ICU of a tertiary care hospital from July 2012 to August
2013. From March 2013, RDIF was made mandatory to be filled
up prior to prescribing reserve antimicrobials. AM consumption
(expressed as DDD/100 bed days) and sensitivity pattern
(expressed in percentage) six months prior to and six months
after implementation of the form were analysed.
Results: The total Reserve AM consumption was 125.79 per
100 bed days during the study period. Average occupancy
index was 0.50 and length of ICU stay was 6 days. The total
consumption reduced from 85.55/100 to 40.24/100 bed days
after the introduction of the RDIF. However, Imipenem usage
increased from 11.35/100 to 23.94/100 bed days, which can be
attributed to sensitivity profile to Imipenem (82.1%) compared to
Meropenem (65.7%). Cost of therapy reduced from Rs 6,27,951
to 4,20,469.
Conclusion: Reserve AM consumption showed a declining trend
after introduction of the RDIF. Hence, the RDIF served as an
important tool to combat inappropriate use, reducing the cost
burden and also helped to improve the sensitivity to reserve
drugs. |
| first_indexed | 2024-12-22T16:16:41Z |
| format | Article |
| id | doaj.art-dbe16126e0614f3e995e8b65f2c4ba0d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T16:16:41Z |
| publishDate | 2015-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-dbe16126e0614f3e995e8b65f2c4ba0d2022-12-21T18:20:22ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-02-0192FC05FC0910.7860/JCDR/2015/10974.5593Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care HospitalDeepthi Shridhar P.0Anitha K.B.1Mohandas Rai2Anisha Fernandes3Postgraduate, Department of Pharmacology, A.J. Institute of Medical Sciences and Research Centre, Mangalore, India.Professor,Department of Microbiology & Co-ordinator HICC, A.J. Institute of Medical Sciences and Research Centre, Mangalore, India.Professor and Head, Department of Pharmacology, A.J. Institute of Medical Sciences and Research Centre, Mangalore, India.Clinical Microbiologist (HICC), Department of Microbiology, A.J. Institute of Medical Sciences and research centre, Mangalore, India.Objectives: A world without effective antibiotics is a terrifying but a real prospect. Overuse or misuse especially of newer and higher antimicrobials (AM) is of particular concern, as this contributes to development of resistance among microorganisms. To check this trend, the Reserve Drug Indent Form (RDIF) was introduced in our hospital and its impact on AM consumption, cost of therapy and the sensitivity pattern was studied in the medical intensive care unit (MICU). Materials and Methods: A retrospective descriptive study in the medical ICU of a tertiary care hospital from July 2012 to August 2013. From March 2013, RDIF was made mandatory to be filled up prior to prescribing reserve antimicrobials. AM consumption (expressed as DDD/100 bed days) and sensitivity pattern (expressed in percentage) six months prior to and six months after implementation of the form were analysed. Results: The total Reserve AM consumption was 125.79 per 100 bed days during the study period. Average occupancy index was 0.50 and length of ICU stay was 6 days. The total consumption reduced from 85.55/100 to 40.24/100 bed days after the introduction of the RDIF. However, Imipenem usage increased from 11.35/100 to 23.94/100 bed days, which can be attributed to sensitivity profile to Imipenem (82.1%) compared to Meropenem (65.7%). Cost of therapy reduced from Rs 6,27,951 to 4,20,469. Conclusion: Reserve AM consumption showed a declining trend after introduction of the RDIF. Hence, the RDIF served as an important tool to combat inappropriate use, reducing the cost burden and also helped to improve the sensitivity to reserve drugs.https://jcdr.net/articles/PDF/5593/10974_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_.pdfantimicrobial resistancedaily defined dosereserve drug indent formsensitivity profile |
| spellingShingle | Deepthi Shridhar P. Anitha K.B. Mohandas Rai Anisha Fernandes Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital Journal of Clinical and Diagnostic Research antimicrobial resistance daily defined dose reserve drug indent form sensitivity profile |
| title | Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital |
| title_full | Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital |
| title_fullStr | Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital |
| title_full_unstemmed | Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital |
| title_short | Reserve Drug Indent Form and Its Impact on Antimicrobial Consumption and Sensitivity Pattern in the Medical Intensive Care Unit of a Tertiary Care Hospital |
| title_sort | reserve drug indent form and its impact on antimicrobial consumption and sensitivity pattern in the medical intensive care unit of a tertiary care hospital |
| topic | antimicrobial resistance daily defined dose reserve drug indent form sensitivity profile |
| url | https://jcdr.net/articles/PDF/5593/10974_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_.pdf |
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