Hypomethylated interferon regulatory factor 8 recruits activating protein-2α to attenuate porcine epidemic diarrhea virus infection in porcine jejunum

Hypomethylated interferon regulatory factor 8 recruits activating protein-2α to attenuate porcine epidemic diarrhea virus infection in porcine jejunum

Interferon regulatory factor 8 (IRF8) is a key regulator of innate immune receptor signaling that resists pathogen invasion by regulating cell growth and differentiation. Porcine epidemic diarrhea virus (PEDV) targets the intestine and damages the mucosal barrier. However, whether IRF8 regulates PED...

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Bibliographic Details
Main Authors: Qiufang Zong, Huan Qu, Xianrui Zheng, Haifei Wang, Shenglong Wu, Zongjun Yin, Wenbin Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
PEDV
IRF8
DNA methylation
AP-2α
oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1187144/full

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