A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins.

A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins.

Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cell physiology, but many of which have no known function. CDKN1A/p21 is an important inhibitor of the cell-cycle, regulator of the DNA damage response and effector of the tumor suppressor p53, playing a crucial role in tumor develop...

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Main Authors: Masamitsu Negishi, Somsakul P Wongpalee, Sukumar Sarkar, Jonghoon Park, Kyung Yong Lee, Yoshiyuki Shibata, Brian J Reon, Roger Abounader, Yutaka Suzuki, Sumio Sugano, Anindya Dutta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3991591?pdf=render

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