DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes
Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine) copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone) propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis- -(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2023-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300063M.pdf |
| _version_ | 1797215525164548096 |
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| author | Mijatović Aleksandar Caković Angelina Z. Lolić Aleksandar Sretenović Snežana Živanović Marko N. Šeklić Dragana S. Bogojeski Jovana Petrović Biljana V. |
| author_facet | Mijatović Aleksandar Caković Angelina Z. Lolić Aleksandar Sretenović Snežana Živanović Marko N. Šeklić Dragana S. Bogojeski Jovana Petrović Biljana V. |
| author_sort | Mijatović Aleksandar |
| collection | DOAJ |
| description | Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine) copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone) propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis- -(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA intercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity. |
| first_indexed | 2024-04-24T11:31:27Z |
| format | Article |
| id | doaj.art-dbe49eebf62a46faa66c818ba9c4dafa |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-04-24T11:31:27Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-dbe49eebf62a46faa66c818ba9c4dafa2024-04-10T10:17:11ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212023-01-0188121307131710.2298/JSC230614063M0352-51392300063MDNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexesMijatović Aleksandar0Caković Angelina Z.1https://orcid.org/0000-0003-3909-4211Lolić Aleksandar2https://orcid.org/0000-0002-5354-9019Sretenović Snežana3https://orcid.org/0009-0002-0515-7931Živanović Marko N.4https://orcid.org/0000-0002-8833-8035Šeklić Dragana S.5https://orcid.org/0000-0002-2093-5335Bogojeski Jovana6Petrović Biljana V.7https://orcid.org/0000-0001-7914-6026University of Belgrade, Faculty of Mining and Geology, Belgrade, SerbiaUniversity of Kragujevac, Faculty of Science, KragujevacUniversity of Belgrade, Faculty of Chemistry, BelgradeUniversity of Kragujevac, Faculty of Medicinal Science, Department of Internal medicine, Kragujevac, SerbiaUniversity of Kragujevac, Institute for Information Technologies Kragujevac, Kragujevac, SerbiaUniversity of Kragujevac, Institute for Information Technologies Kragujevac, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Science, KragujevacUniversity of Kragujevac, Faculty of Science, KragujevacThree Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine) copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone) propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis- -(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA intercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity.https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300063M.pdfantitumormechanismcell linebiomoleculeaffinitydrug design |
| spellingShingle | Mijatović Aleksandar Caković Angelina Z. Lolić Aleksandar Sretenović Snežana Živanović Marko N. Šeklić Dragana S. Bogojeski Jovana Petrović Biljana V. DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes Journal of the Serbian Chemical Society antitumor mechanism cell line biomolecule affinity drug design |
| title | DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes |
| title_full | DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes |
| title_fullStr | DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes |
| title_full_unstemmed | DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes |
| title_short | DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes |
| title_sort | dna bsa interactions and cytotoxic studies of tetradentate n n o o schiff base copper ii complexes |
| topic | antitumor mechanism cell line biomolecule affinity drug design |
| url | https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300063M.pdf |
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