Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center

Abstract Background This is an exploratory research of cystoprostatectomy (CP) in treating prostate cancer (PCa) extending to the bladder, which aimed to evaluate the effects of CP on survival outcomes and improving quality of life (QoL) in these patients. Methods A total of 27 PCa patients extendin...

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Main Authors: Xiaoliang Sun, Min Liu, Yong Zhao, Kang Leng, Haiyang Zhang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Urology
Subjects:
Online Access:https://doi.org/10.1186/s12894-022-01068-7
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author Xiaoliang Sun
Min Liu
Yong Zhao
Kang Leng
Haiyang Zhang
author_facet Xiaoliang Sun
Min Liu
Yong Zhao
Kang Leng
Haiyang Zhang
author_sort Xiaoliang Sun
collection DOAJ
description Abstract Background This is an exploratory research of cystoprostatectomy (CP) in treating prostate cancer (PCa) extending to the bladder, which aimed to evaluate the effects of CP on survival outcomes and improving quality of life (QoL) in these patients. Methods A total of 27 PCa patients extending to the bladder were subjected to CP and followed up at regular intervals in our center. Prostate cancer-specific survival (PCSS) and prostate-specific antigen recurrence-free survival (PFS) were assessed by Kaplan–Meier analysis. Multivariate Cox regression was performed to evaluate clinical characteristics predicting survivals. QoL and pelvic symptoms were also evaluated. Results Median PCSS was not reached over the period of follow-up. 5-year PCSS rate was 82.1%. Median PFS was 66.0 months. 5-year PFS rate was 58.5%. Multivariate analysis showed Gleason score (≥ 8) (hazard ratio (HR) 2.55, 95% confidence interval (CI) 1.28–4.04, p = 0.033), positive local lymph node status (HR 3.52, 95% CI 1.57–7.38, p = 0.006) and bladder muscle-invasion (HR 4.75, 95% CI 1.37–7.53, p < 0.001) were independent predictors of worse PCSS. The number of patients suffering pelvic symptoms was significantly decreased, and QoL scores were significantly down-regulated after surgeries. Conclusion CP offered effective and durable palliation in patients of locally advanced prostate cancer with invasion of the bladder, providing better QoL and relieving local symptoms.
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spelling doaj.art-dbe4db607613426eab1391323ce0b5612022-12-22T00:58:25ZengBMCBMC Urology1471-24902022-07-012211810.1186/s12894-022-01068-7Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single centerXiaoliang Sun0Min Liu1Yong Zhao2Kang Leng3Haiyang Zhang4Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Oncologic Chemotherapy, Shandong Second Provincial General HospitalDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityAbstract Background This is an exploratory research of cystoprostatectomy (CP) in treating prostate cancer (PCa) extending to the bladder, which aimed to evaluate the effects of CP on survival outcomes and improving quality of life (QoL) in these patients. Methods A total of 27 PCa patients extending to the bladder were subjected to CP and followed up at regular intervals in our center. Prostate cancer-specific survival (PCSS) and prostate-specific antigen recurrence-free survival (PFS) were assessed by Kaplan–Meier analysis. Multivariate Cox regression was performed to evaluate clinical characteristics predicting survivals. QoL and pelvic symptoms were also evaluated. Results Median PCSS was not reached over the period of follow-up. 5-year PCSS rate was 82.1%. Median PFS was 66.0 months. 5-year PFS rate was 58.5%. Multivariate analysis showed Gleason score (≥ 8) (hazard ratio (HR) 2.55, 95% confidence interval (CI) 1.28–4.04, p = 0.033), positive local lymph node status (HR 3.52, 95% CI 1.57–7.38, p = 0.006) and bladder muscle-invasion (HR 4.75, 95% CI 1.37–7.53, p < 0.001) were independent predictors of worse PCSS. The number of patients suffering pelvic symptoms was significantly decreased, and QoL scores were significantly down-regulated after surgeries. Conclusion CP offered effective and durable palliation in patients of locally advanced prostate cancer with invasion of the bladder, providing better QoL and relieving local symptoms.https://doi.org/10.1186/s12894-022-01068-7CystoprostatectomyProstate cancerProstate cancer-specific survivalQuality of life
spellingShingle Xiaoliang Sun
Min Liu
Yong Zhao
Kang Leng
Haiyang Zhang
Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center
BMC Urology
Cystoprostatectomy
Prostate cancer
Prostate cancer-specific survival
Quality of life
title Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center
title_full Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center
title_fullStr Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center
title_full_unstemmed Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center
title_short Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center
title_sort evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder a retrospective study from single center
topic Cystoprostatectomy
Prostate cancer
Prostate cancer-specific survival
Quality of life
url https://doi.org/10.1186/s12894-022-01068-7
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